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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F11%3A00365895%21RIV12-AV0-68081707
rdf:type
n17:Vysledek skos:Concept
dcterms:description
The new antitumor monofunctional Ru(II)-arene complex [eta6-arene)Ru(II)(en)Cl]+, where en = [1,2-diaminoethane and the arene is para-terphenyl] inhibits growth of the cancer cells through induction of apoptotic cell death and G0/G1 cell cycle arrest. Further investigations have shown that the ruthenium complex induces apoptosis by regulating the expression of Bc1-2 family proteins. The new antitumor monofunctional Ru(II)-arene complex [eta6-arene)Ru(II)(en)Cl]+, where en = [1,2-diaminoethane and the arene is para-terphenyl] inhibits growth of the cancer cells through induction of apoptotic cell death and G0/G1 cell cycle arrest. Further investigations have shown that the ruthenium complex induces apoptosis by regulating the expression of Bc1-2 family proteins.
dcterms:title
Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand
skos:prefLabel
Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand
skos:notation
RIV/68081707:_____/11:00365895!RIV12-AV0-68081707
n17:predkladatel
n20:ico%3A68081707
n3:aktivita
n10:Z n10:P
n3:aktivity
P(GD301/09/H004), P(LC06030), P(OC09018), Z(AV0Z50040507), Z(AV0Z50040702)
n3:cisloPeriodika
3
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n14:8920184 n14:4713192 n14:4571932
n3:druhVysledku
n15:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
194565
n3:idVysledku
RIV/68081707:_____/11:00365895
n3:jazykVysledku
n19:eng
n3:klicovaSlova
ruthenium; antitumor; cellular response
n3:klicoveSlovo
n5:cellular%20response n5:antitumor n5:ruthenium
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[4A9253D645A5]
n3:nazevZdroje
MOLECULAR PHARMACEUTICS
n3:obor
n16:BO
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:projekt
n7:LC06030 n7:GD301%2F09%2FH004 n7:OC09018
n3:rokUplatneniVysledku
n12:2011
n3:svazekPeriodika
8
n3:tvurceVysledku
Habtemariam, A. Sadler, P. J. Brabec, V. Kašpárková, Jana Zerzánková, Lenka Kisová-Halámiková, Anna
n3:wos
000291233800032
n3:zamer
n13:AV0Z50040507 n13:AV0Z50040702
s:issn
1543-8384
s:numberOfPages
9
n18:doi
10.1021/mp200105d