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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F11%3A00365862%21RIV12-AV0-68081707
rdf:type
skos:Concept n18:Vysledek
dcterms:description
AhR-mediated activity of five selected MeBaP isomers was estimated in the DR-CALUX reporter gene assay performed in rat hepatoma cells. We identified 1-MeBaP as the most potent inducer of AhR activation, stable DNA adduct formation, checkpoint kinase 1 and p53 phosphorylation, and apoptosis. These effects suggest that 1-MeBaP is a potent genotoxin eliciting a typical sequence of events ascribed to carcinogenic PAHs. Importantly, 1-MeBaP and 3-MeBaP were found to be potent AhR agonists, 1 order of magnitude more potent than BaP, thus suggesting that the AhR-dependent modulations of gene expression, deregulation of cell survival mechanisms, and further nongenotoxic effects associated with AhR activation may further contribute to their tumor promotion and carcinogenicity. AhR-mediated activity of five selected MeBaP isomers was estimated in the DR-CALUX reporter gene assay performed in rat hepatoma cells. We identified 1-MeBaP as the most potent inducer of AhR activation, stable DNA adduct formation, checkpoint kinase 1 and p53 phosphorylation, and apoptosis. These effects suggest that 1-MeBaP is a potent genotoxin eliciting a typical sequence of events ascribed to carcinogenic PAHs. Importantly, 1-MeBaP and 3-MeBaP were found to be potent AhR agonists, 1 order of magnitude more potent than BaP, thus suggesting that the AhR-dependent modulations of gene expression, deregulation of cell survival mechanisms, and further nongenotoxic effects associated with AhR activation may further contribute to their tumor promotion and carcinogenicity.
dcterms:title
Toxic Effects of Methylated Benzo[a]pyrenes in Rat Liver Stem-Like Cells Toxic Effects of Methylated Benzo[a]pyrenes in Rat Liver Stem-Like Cells
skos:prefLabel
Toxic Effects of Methylated Benzo[a]pyrenes in Rat Liver Stem-Like Cells Toxic Effects of Methylated Benzo[a]pyrenes in Rat Liver Stem-Like Cells
skos:notation
RIV/68081707:_____/11:00365862!RIV12-AV0-68081707
n18:predkladatel
n20:ico%3A68081707
n3:aktivita
n13:P n13:Z
n3:aktivity
P(GA525/08/1590), Z(AV0Z50040702), Z(AV0Z50390512), Z(MZE0002716202)
n3:cisloPeriodika
6
n3:dodaniDat
n11:2012
n3:domaciTvurceVysledku
n14:2301229
n3:druhVysledku
n9:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
235646
n3:idVysledku
RIV/68081707:_____/11:00365862
n3:jazykVysledku
n6:eng
n3:klicovaSlova
Ah receptor; DNA adducts; WB F344 cells
n3:klicoveSlovo
n4:WB%20F344%20cells n4:Ah%20receptor n4:DNA%20adducts
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[20D58962D718]
n3:nazevZdroje
Chemical Research in Toxicology
n3:obor
n16:DN
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
13
n3:projekt
n15:GA525%2F08%2F1590
n3:rokUplatneniVysledku
n11:2011
n3:svazekPeriodika
24
n3:tvurceVysledku
Pěnčíková, K. Pálková, L. Trilecová, L. Ciganek, M. Milcová, Alena Topinka, Jan Krčmář, P. Neča, J. Hulínková, P. Marvanová, S. Krčková, S. Machala, M. Vondráček, Jan
n3:wos
000291896700011
n3:zamer
n10:MZE0002716202 n10:AV0Z50040702 n10:AV0Z50390512
s:issn
0893-228X
s:numberOfPages
11
n19:doi
10.1021/tx200049x