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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F10%3A00353777%21RIV11-MSM-68081707
rdf:type
skos:Concept n17:Vysledek
dcterms:description
The organic cation transporters play a more important role in the mechanism of cytotoxicity of JM118 than in the cytotoxicity of cisplatin. Satraplatin is a poor substrate of these transporters. Satraplatin reacts with glutathione with the rate markedly lower than JM118 and cisplatin. Satraplatin can be activated by glutathione allowing it to react with DNA. The organic cation transporters play a more important role in the mechanism of cytotoxicity of JM118 than in the cytotoxicity of cisplatin. Satraplatin is a poor substrate of these transporters. Satraplatin reacts with glutathione with the rate markedly lower than JM118 and cisplatin. Satraplatin can be activated by glutathione allowing it to react with DNA.
dcterms:title
Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione
skos:prefLabel
Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione
skos:notation
RIV/68081707:_____/10:00353777!RIV11-MSM-68081707
n3:aktivita
n11:P n11:Z
n3:aktivity
P(GAP301/10/0598), P(IAA400040803), P(ME08017), P(ME10066), P(OC08003), Z(AV0Z50040507), Z(AV0Z50040702)
n3:cisloPeriodika
6
n3:dodaniDat
n15:2011
n3:domaciTvurceVysledku
n4:7988346 n4:6345522 n4:4571932
n3:druhVysledku
n7:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
290639
n3:idVysledku
RIV/68081707:_____/10:00353777
n3:jazykVysledku
n18:eng
n3:klicovaSlova
JM118; cellular accumulation; glutathione
n3:klicoveSlovo
n16:cellular%20accumulation n16:JM118 n16:glutathione
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[D70AE45FC365]
n3:nazevZdroje
MOLECULAR PHARMACEUTICS
n3:obor
n6:BO
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n5:IAA400040803 n5:ME08017 n5:GAP301%2F10%2F0598 n5:OC08003 n5:ME10066
n3:rokUplatneniVysledku
n15:2010
n3:svazekPeriodika
7
n3:tvurceVysledku
Kašpárková, Jana Brabec, Viktor Gibson, D. Kostrhunová, Hana
n3:wos
000284865900020
n3:zamer
n10:AV0Z50040702 n10:AV0Z50040507
s:issn
1543-8384
s:numberOfPages
10