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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F09%3A00345305%21RIV11-AV0-68081707
rdf:type
skos:Concept n14:Vysledek
dcterms:description
In the present study we demonstrated qualitative differences in the DNA damage profiles produced by hepatocarcinogens DBC and DiMeDBC in WB-F344 liver cells. Different lesions may trigger distinct cellular pathways involved in hepatocarcinogenesis. The low amount of DNA damage, together with an efficient repair, may explain the lack of hepatocarcinogenicity of N-MeDBC derivative. In the present study we demonstrated qualitative differences in the DNA damage profiles produced by hepatocarcinogens DBC and DiMeDBC in WB-F344 liver cells. Different lesions may trigger distinct cellular pathways involved in hepatocarcinogenesis. The low amount of DNA damage, together with an efficient repair, may explain the lack of hepatocarcinogenicity of N-MeDBC derivative.
dcterms:title
Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells
skos:prefLabel
Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells
skos:notation
RIV/68081707:_____/09:00345305!RIV11-AV0-68081707
n3:aktivita
n8:Z n8:P
n3:aktivity
P(2B08005), P(SP/1B3/8/08), Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50390512), Z(MZE0002716201)
n3:cisloPeriodika
1-2
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n17:2301229
n3:druhVysledku
n15:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
310456
n3:idVysledku
RIV/68081707:_____/09:00345305
n3:jazykVysledku
n12:eng
n3:klicovaSlova
DNA adducts; DNA strand breaks; oxidative stress
n3:klicoveSlovo
n7:oxidative%20stress n7:DNA%20adducts n7:DNA%20strand%20breaks
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[5919D7E1CBAD]
n3:nazevZdroje
Mutation Research
n3:obor
n16:BO
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:projekt
n9:2B08005 n9:SP%2F1B3%2F8%2F08
n3:rokUplatneniVysledku
n10:2009
n3:svazekPeriodika
665
n3:tvurceVysledku
Trilecová, L. Milcová, A. Líbalová, H. Marvanová, S. Valovičová, Z. Srančíková, A. Machala, M. Mészárosová, M. Topinka, J. Vondráček, Jan Gábelová, A.
n3:wos
000266690200008
n3:zamer
n13:MZE0002716201 n13:AV0Z50040507 n13:AV0Z50040702 n13:AV0Z50390512
s:issn
0027-5107
s:numberOfPages
10