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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F09%3A00329490%21RIV10-MSM-68081707
rdf:type
n11:Vysledek skos:Concept
dcterms:description
We have examined activity of 12 Pt(II)-based DNA intercalators of the type [Pt(IL)(AL)]2+, where IL is an intercalating ligand (1,10-phenanthroline or a methylated derivative) and AL is an ancillary ligand (diaminocyclohexane, diphenylethylenediamine or 1,2-bis(4-fluorophenyl)-1,2-ethylenediamine) against a panel of human cancer cell lines and further in vitro testing was conducted to provide information about the mechanism of action. We have examined activity of 12 Pt(II)-based DNA intercalators of the type [Pt(IL)(AL)]2+, where IL is an intercalating ligand (1,10-phenanthroline or a methylated derivative) and AL is an ancillary ligand (diaminocyclohexane, diphenylethylenediamine or 1,2-bis(4-fluorophenyl)-1,2-ethylenediamine) against a panel of human cancer cell lines and further in vitro testing was conducted to provide information about the mechanism of action.
dcterms:title
Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells
skos:prefLabel
Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells
skos:notation
RIV/68081707:_____/09:00329490!RIV10-MSM-68081707
n3:aktivita
n4:Z n4:P
n3:aktivity
P(1QS500040581), P(IAA400040803), P(KAN200200651), P(LC06030), P(ME08017), P(OC08003), P(OC09018), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM6198959216)
n3:cisloPeriodika
17
n3:dodaniDat
n14:2010
n3:domaciTvurceVysledku
n10:7988346 n10:9286667 n10:4571932
n3:druhVysledku
n7:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
344350
n3:idVysledku
RIV/68081707:_____/09:00329490
n3:jazykVysledku
n12:eng
n3:klicovaSlova
platinum; metallointercalator; cytotoxicity
n3:klicoveSlovo
n6:metallointercalator n6:cytotoxicity n6:platinum
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[025340A3A1DF]
n3:nazevZdroje
Journal of Medicinal Chemistry
n3:obor
n18:AQ
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
13
n3:projekt
n5:1QS500040581 n5:KAN200200651 n5:OC08003 n5:ME08017 n5:LC06030 n5:IAA400040803 n5:OC09018
n3:rokUplatneniVysledku
n14:2009
n3:svazekPeriodika
52
n3:tvurceVysledku
Kašpárková, Jana Le Pevelen, D. D. Fisher, D. M. Kühne, S. Wheate, N. J. Boag, L. R. Buczkowska, M. Aldrich-Wright, J. R. Krause-Heuer, A. M. Brabec, Viktor Bednarski, P. J. Malina, Jaroslav Grüner, R.
n3:wos
000269655500020
n3:zamer
n15:MSM6198959216 n15:AV0Z50040507 n15:AV0Z50040702
s:issn
0022-2623
s:numberOfPages
11