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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F09%3A00327497%21RIV10-AV0-68081707
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 is accompanied by activation of pro-apoptotic kinases p38 and JNK and caspases 8 and 9. Pharmacologic inhibition of those processes resulted in a decreased amount of differentiated cells, which illustrates the importance of those signaling pathways in monocytic differentiation of leukemic cells. Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 is accompanied by activation of pro-apoptotic kinases p38 and JNK and caspases 8 and 9. Pharmacologic inhibition of those processes resulted in a decreased amount of differentiated cells, which illustrates the importance of those signaling pathways in monocytic differentiation of leukemic cells.
dcterms:title
Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery
skos:prefLabel
Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery
skos:notation
RIV/68081707:_____/09:00327497!RIV10-AV0-68081707
n4:aktivita
n6:Z n6:S n6:P
n4:aktivity
P(1QS500040507), P(GP524/06/P345), S, Z(AV0Z50040507), Z(AV0Z50040702)
n4:cisloPeriodika
1
n4:dodaniDat
n9:2010
n4:domaciTvurceVysledku
n7:3101630 n7:9620893 n7:1075020 n7:1706063 n7:3283038
n4:druhVysledku
n12:J
n4:duvernostUdaju
n5:S
n4:entitaPredkladatele
n8:predkladatel
n4:idSjednocenehoVysledku
327400
n4:idVysledku
RIV/68081707:_____/09:00327497
n4:jazykVysledku
n16:eng
n4:klicovaSlova
caspases; MAPK; MK886
n4:klicoveSlovo
n13:caspases n13:MK886 n13:MAPK
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[7925E7200B22]
n4:nazevZdroje
European Journal of Haematology
n4:obor
n18:BO
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
5
n4:projekt
n14:GP524%2F06%2FP345 n14:1QS500040507
n4:rokUplatneniVysledku
n9:2009
n4:svazekPeriodika
83
n4:tvurceVysledku
Hofmanová, Jiřina Kozubík, Alois Souček, Karel Stixová, Lenka Procházková, Jiřina
n4:wos
000266875000004
n4:zamer
n17:AV0Z50040702 n17:AV0Z50040507
s:issn
0902-4441
s:numberOfPages
13