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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F08%3A00305724%21RIV08-AV0-68081707
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Korelace mezi jaderným uspořádáním a transkripční aktivitou Oct4 a c-myc genů byly studovány u lidských embryonálních kmenových buněk (hESC) stimulovaných k diferenciaci. Jaderná distribuce všech variant HP1 proteinu byla navíc testována v tomto experimentálním systému. Struktury zodpovědné za hESC pluripotentnost byly charakteristické větší mírou de-kondenzace, než struktury, takové jako je c-myc gen, zodpovědné za regulaci buněčného cyklu nebo indukci diferenciace. Nuclear arrangement, in correlation with transcriptional activity, of 0ct4 and the c-myc gene was investigated in human embryonic stem cells (hESC) undergoing differentiation. Additionally, nuclear distribution of all subtypes of HP1 protein was studied in this experimental system. The structures responsible for hESC pluripotency were characterized by more de-condensed nuclear arrangement, while more conserved nuclear topography was found for structures responsible for cell cycle regulation and/or differentiation, such as the c-myc gene. Nuclear arrangement, in correlation with transcriptional activity, of 0ct4 and the c-myc gene was investigated in human embryonic stem cells (hESC) undergoing differentiation. Additionally, nuclear distribution of all subtypes of HP1 protein was studied in this experimental system. The structures responsible for hESC pluripotency were characterized by more de-condensed nuclear arrangement, while more conserved nuclear topography was found for structures responsible for cell cycle regulation and/or differentiation, such as the c-myc gene.
dcterms:title
Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci Diferenciace lidských embryonálních kmenových buněk indukuje kondenzaci chromosomálních teritorií a tvorbu ohnisek HP+ proteinu
skos:prefLabel
Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci Diferenciace lidských embryonálních kmenových buněk indukuje kondenzaci chromosomálních teritorií a tvorbu ohnisek HP+ proteinu Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci
skos:notation
RIV/68081707:_____/08:00305724!RIV08-AV0-68081707
n3:strany
1;9
n3:aktivita
n12:Z n12:P
n3:aktivity
P(1P05OC084), P(1QS500040508), P(GA204/06/0978), P(IAA5004306), P(LC535), Z(AV0Z50040507), Z(AV0Z50040702)
n3:cisloPeriodika
1
n3:dodaniDat
n6:2008
n3:domaciTvurceVysledku
n4:4873130 n4:1587242 n4:8830797 n4:8491313
n3:druhVysledku
n13:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
363575
n3:idVysledku
RIV/68081707:_____/08:00305724
n3:jazykVysledku
n17:eng
n3:klicovaSlova
differentiation; human embryonic stem cells; chromatin structure
n3:klicoveSlovo
n10:differentiation n10:human%20embryonic%20stem%20cells n10:chromatin%20structure
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[1A4948DD2438]
n3:nazevZdroje
Differentiation
n3:obor
n15:BO
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n9:GA204%2F06%2F0978 n9:1QS500040508 n9:LC535 n9:1P05OC084 n9:IAA5004306
n3:rokUplatneniVysledku
n6:2008
n3:svazekPeriodika
76
n3:tvurceVysledku
Bártová, Eva Harničarová, Andrea Kozubek, Stanislav Kroupová, Jana
n3:zamer
n8:AV0Z50040702 n8:AV0Z50040507
s:issn
0301-4681
s:numberOfPages
9