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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F07%3A00085551%21RIV08-AV0-68081707
rdf:type
skos:Concept n17:Vysledek
dcterms:description
TNF-alpha is known to play a major role in liver regeneration as well as in carcinogenesis. We investigated possible interaction of TNF-alpha with ligands of the AhR. TNF-alpha significantly potentiated proliferative effects of TCDD and PCB126 leading to an increased percentage of cells in S-phase of cell cycle and increased expression of cyclin A. TNF-alpha inhibited AhR-dependent induction of CYP1A1, in contrast, it enhanced induction of CYP1B1. TNF-alpha is known to play a major role in liver regeneration as well as in carcinogenesis. We investigated possible interaction of TNF-alpha with ligands of the AhR. TNF-alpha significantly potentiated proliferative effects of TCDD and PCB126 leading to an increased percentage of cells in S-phase of cell cycle and increased expression of cyclin A. TNF-alpha inhibited AhR-dependent induction of CYP1A1, in contrast, it enhanced induction of CYP1B1. TNF-alfa hraje důležitou roli během procesu jaterní regenerace, stejně jako při vzniku karcinogeneze. V této práci se zabýváme možnou interakcí TNF-alfa s ligandy AhR. TNF-alfa významně posiluje proliferační účinky TCDD a PCB126, což vede ke zvýšení procenta buněk v S-fázi buněčného cyklu a zvýšenou expresi cyklinu A. TNF-alfa inhibuje AhR-dependentní indukci CYP1A1 a naopak posiluje expresi CYP1B1.
dcterms:title
Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells TNF-alfa se podílí na proliferaci a změně exprese enzymů cytochromu P450 indukovaných působením ligandů Ah receptoru u potkaních jaterních buněk Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells
skos:prefLabel
Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells TNF-alfa se podílí na proliferaci a změně exprese enzymů cytochromu P450 indukovaných působením ligandů Ah receptoru u potkaních jaterních buněk
skos:notation
RIV/68081707:_____/07:00085551!RIV08-AV0-68081707
n3:strany
79;89
n3:aktivita
n9:P n9:Z
n3:aktivity
P(GA524/05/0595), Z(AV0Z50040507), Z(AV0Z50040702)
n3:cisloPeriodika
1
n3:dodaniDat
n8:2008
n3:domaciTvurceVysledku
n5:1706063 n5:2301229 n5:2499304 n5:3547884
n3:druhVysledku
n10:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
455972
n3:idVysledku
RIV/68081707:_____/07:00085551
n3:jazykVysledku
n18:eng
n3:klicovaSlova
tumor necrosis factor-alpha; xenobiotic metabolizing enzymes; dioxin
n3:klicoveSlovo
n13:dioxin n13:xenobiotic%20metabolizing%20enzymes n13:tumor%20necrosis%20factor-alpha
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[170141879844]
n3:nazevZdroje
Toxicological Sciences
n3:obor
n15:BO
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
8
n3:projekt
n16:GA524%2F05%2F0595
n3:rokUplatneniVysledku
n8:2007
n3:svazekPeriodika
99
n3:tvurceVysledku
Májková, Z. Hennig, B. Zatloukalová, Jiřina Machala, M. Umannová, Lenka Krčmář, P. Vondráček, Jan Kozubík, Alois
n3:zamer
n12:AV0Z50040507 n12:AV0Z50040702
s:issn
0388-1350
s:numberOfPages
11