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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F05%3A00022152%21RIV11-GA0-68081707
rdf:type
n18:Vysledek skos:Concept
dcterms:description
In the present study, we investigated impact of silymarin, its constituents and a series of their synthetic derivatives on ER- and AhR-mediated activities. Silymarin elicited partial ER activation, with silybin B being probably responsible for a majority of the weak ER-mediated activity of silymarin, while the synthetic silybin derivatives, potentially useful as chemoprotective agents, did not modulate the ER-mediated activity, with exception of 23-O-pivaloylsilybin. In conclusion, our data suggest that estrogenicity of some silymarin constituents, and biological activities of their purified or synthesized diastereomers, should be taken in account as their potential side effect when considered as chemopreventive compounds. In the present study, we investigated impact of silymarin, its constituents and a series of their synthetic derivatives on ER- and AhR-mediated activities. Silymarin elicited partial ER activation, with silybin B being probably responsible for a majority of the weak ER-mediated activity of silymarin, while the synthetic silybin derivatives, potentially useful as chemoprotective agents, did not modulate the ER-mediated activity, with exception of 23-O-pivaloylsilybin. In conclusion, our data suggest that estrogenicity of some silymarin constituents, and biological activities of their purified or synthesized diastereomers, should be taken in account as their potential side effect when considered as chemopreventive compounds.
dcterms:title
Effect of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation Effect of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation
skos:prefLabel
Effect of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation Effect of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation
skos:notation
RIV/68081707:_____/05:00022152!RIV11-GA0-68081707
n3:aktivita
n4:P n4:Z
n3:aktivity
P(GA303/02/1097), Z(AV0Z50040507), Z(AV0Z50200510)
n3:cisloPeriodika
1-2
n3:dodaniDat
n15:2011
n3:domaciTvurceVysledku
n17:2301229
n3:druhVysledku
n16:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
519434
n3:idVysledku
RIV/68081707:_____/05:00022152
n3:jazykVysledku
n10:eng
n3:klicovaSlova
estrogenicity; dioxin-like activity; silybin derivatives
n3:klicoveSlovo
n8:estrogenicity n8:dioxin-like%20activity n8:silybin%20derivatives
n3:kodStatuVydavatele
IE - Irsko
n3:kontrolniKodProRIV
[7C03676B3A12]
n3:nazevZdroje
Toxicology
n3:obor
n13:BO
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:projekt
n12:GA303%2F02%2F1097
n3:rokUplatneniVysledku
n15:2005
n3:svazekPeriodika
215
n3:tvurceVysledku
Machala, M. Gažák, Radek Vondráček, Jan Křen, Vladimír Plíšková, M. Psotová, J. Sedmera, Petr Walterová, D. Šimánek, V.
n3:wos
000233125300007
n3:zamer
n9:AV0Z50200510 n9:AV0Z50040507
s:issn
0300-483X
s:numberOfPages
10