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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F05%3A00001331%21RIV06-AV0-68081707
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Effects of adducts of [PtCl(NH3)(3)] Cl or chlorodiethylenetriamineplatinum(II) on DNA stability were studied with emphasis on thermodynamic origins of that stability. Oligodeoxyribonucleotide duplexes (15-bp) containing the single, site-specific monofunctional adduct at G-residues of the central sequences TGT/ACA or 5'-AGT/ 5'-ACT were prepared and analyzed by differential scanning calorimetry, temperature-dependent ultraviolet absorption and circular dichroism. The unfolding of the platinated duplexes was accompanied by relatively small unfavorable free energy terms. This destabilization was enthalpic in origin. On the other hand, a relatively large reduction of melting temperature (T-m) was observed as a consequence of the monofunctional adduct in the TGT sequence, whereas T-m due to the adduct in the AGT sequence was reduced only slightly. Byl popsán vliv vzniku monofunkčních aduktů platnatých komplexů na termodynamickou stabilitu DNA a důsledky vyvolaných změn v termodynamické stabilitě modifikované DNA na její opravu složkami excisní nukleotidové opravy. Effects of adducts of [PtCl(NH3)(3)] Cl or chlorodiethylenetriamineplatinum(II) on DNA stability were studied with emphasis on thermodynamic origins of that stability. Oligodeoxyribonucleotide duplexes (15-bp) containing the single, site-specific monofunctional adduct at G-residues of the central sequences TGT/ACA or 5'-AGT/ 5'-ACT were prepared and analyzed by differential scanning calorimetry, temperature-dependent ultraviolet absorption and circular dichroism. The unfolding of the platinated duplexes was accompanied by relatively small unfavorable free energy terms. This destabilization was enthalpic in origin. On the other hand, a relatively large reduction of melting temperature (T-m) was observed as a consequence of the monofunctional adduct in the TGT sequence, whereas T-m due to the adduct in the AGT sequence was reduced only slightly.
dcterms:title
Vliv monofunkčních aduktů platnatých komplexů na termodynamickou stabilitu a energetiku duplexů DNA Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes
skos:prefLabel
Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes Vliv monofunkčních aduktů platnatých komplexů na termodynamickou stabilitu a energetiku duplexů DNA Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes
skos:notation
RIV/68081707:_____/05:00001331!RIV06-AV0-68081707
n3:strany
1207;1214
n3:aktivita
n14:P n14:Z
n3:aktivity
P(GA305/02/1552), P(GD204/03/H016), P(IAA5004101), P(KJB5004301), P(OC D20.004), Z(AV0Z50040507)
n3:cisloPeriodika
2
n3:dodaniDat
n15:2006
n3:domaciTvurceVysledku
n5:9914048 n5:1573292 n5:7988346 n5:4571932
n3:druhVysledku
n7:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
519596
n3:idVysledku
RIV/68081707:_____/05:00001331
n3:jazykVysledku
n9:eng
n3:klicovaSlova
DNA; platinum; cancer
n3:klicoveSlovo
n4:platinum n4:DNA n4:cancer
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[59DF8926F675]
n3:nazevZdroje
Biophysical Journal
n3:obor
n18:BO
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n11:KJB5004301 n11:IAA5004101 n11:GA305%2F02%2F1552 n11:OC%20D20.004 n11:GD204%2F03%2FH016
n3:rokUplatneniVysledku
n15:2005
n3:svazekPeriodika
88
n3:tvurceVysledku
Brabec, Viktor Kašpárková, Jana Bursová, Vendula Hofr, Ctirad
n3:zamer
n17:AV0Z50040507
s:issn
0006-3495
s:numberOfPages
8