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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F05%3A00001323%21RIV06-AV0-68081707
rdf:type
n12:Vysledek skos:Concept
dcterms:description
The effect of the location of the interstrand cross-link formed by trans-diamminedichloroplatinum(H) (transplatin) on the thermal stability and energetics of 15-mer DNA duplex has been investigated. The duplex containing single, site-specific cross-link, thermodynamically equivalent model structures (hairpins) and nonmodified duplexes were characterized by differential scanning calorimetry, temperature-dependent uv absorption, and circular dichroism. The results demonstrate that the formation of the interstrand cross-link of transplatin does not affect pronouncedly thermodynamic stability of DNA: the cross-link induces no marked changes not only in enthalpy, but also in %22reduced%22 (concentration independent) monomolecular transition entropy. These results are consistent with the previous observations that interstrand cross-links of transplatin structurally perturb DNA only to a relatively small extent. Byl studován vliv polohy meziřetězcového můstku vytvořeného trans-dimmindichloroplatnatým komplexem (transplatinou) na tepelnou a termodynamickou stabilitu DNA pomocí diferenční skenovací kalorimetrie. Bylo zjištěno, že poloha můstku v duplexu DNA moduluje kooperativitu procesu tání duplexu a následně také tepelnou stabilitu. The effect of the location of the interstrand cross-link formed by trans-diamminedichloroplatinum(H) (transplatin) on the thermal stability and energetics of 15-mer DNA duplex has been investigated. The duplex containing single, site-specific cross-link, thermodynamically equivalent model structures (hairpins) and nonmodified duplexes were characterized by differential scanning calorimetry, temperature-dependent uv absorption, and circular dichroism. The results demonstrate that the formation of the interstrand cross-link of transplatin does not affect pronouncedly thermodynamic stability of DNA: the cross-link induces no marked changes not only in enthalpy, but also in %22reduced%22 (concentration independent) monomolecular transition entropy. These results are consistent with the previous observations that interstrand cross-links of transplatin structurally perturb DNA only to a relatively small extent.
dcterms:title
Thermal stability and energetics of 15-mer DNA duplex interstrand crosslinked by trans-diamminedichloroplatinum(II) Tepelná stabilita a energetika duplexu DNA 15 párů bází dlouhého obsahujícího meziřetězcový můstek trans-dimmindichloroplatnatého komplexu Thermal stability and energetics of 15-mer DNA duplex interstrand crosslinked by trans-diamminedichloroplatinum(II)
skos:prefLabel
Tepelná stabilita a energetika duplexu DNA 15 párů bází dlouhého obsahujícího meziřetězcový můstek trans-dimmindichloroplatnatého komplexu Thermal stability and energetics of 15-mer DNA duplex interstrand crosslinked by trans-diamminedichloroplatinum(II) Thermal stability and energetics of 15-mer DNA duplex interstrand crosslinked by trans-diamminedichloroplatinum(II)
skos:notation
RIV/68081707:_____/05:00001323!RIV06-AV0-68081707
n3:strany
222;229
n3:aktivita
n6:Z n6:P
n3:aktivity
P(GA305/02/1552), P(GP202/01/D110), P(LZ1K03010), Z(AV0Z50040507)
n3:cisloPeriodika
4
n3:dodaniDat
n4:2006
n3:domaciTvurceVysledku
n13:9914048 n13:7988346
n3:druhVysledku
n16:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
546689
n3:idVysledku
RIV/68081707:_____/05:00001323
n3:jazykVysledku
n14:eng
n3:klicovaSlova
DNA; interstrand cross-link; transplatin
n3:klicoveSlovo
n9:interstrand%20cross-link n9:transplatin n9:DNA
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[379BD88B95B3]
n3:nazevZdroje
Biopolymers
n3:obor
n7:BO
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n8:GA305%2F02%2F1552 n8:GP202%2F01%2FD110 n8:LZ1K03010
n3:rokUplatneniVysledku
n4:2005
n3:svazekPeriodika
77
n3:tvurceVysledku
Hofr, Ctirad Brabec, Viktor
n3:zamer
n17:AV0Z50040507
s:issn
0006-3525
s:numberOfPages
8