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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F04%3A00108489%21RIV%2F2005%2FAV0%2FA17005%2FN
rdf:type
n11:Vysledek skos:Concept
dcterms:description
V předkládané studii byly pomocí vysokokapacitních cDNA čipu obsahujících 19,000 sekvencí, provedeny studie expresních profilů promyelotických leukemických buněk HL-60 diferencujících do monocytů (MD) a granulocytů (GD). Jako diferenciační činidlo pro monocytární diferenciaci bylo použito TPA (12-O-tetradecanoylphorbol-D-acetate) a pro granulocytární proces DMSO. Studiem expresních profilů bylo zjištěno že v průběhu MD signifikantně měnilo expresi 4625 genů a v průběhu GD 4760 genů. Geny obou diferenciací byly rozděleny do podle typu kinetiky s jakou se účastní diferenciace do tzv. R-skupin. Bylo zjištěno, že geny z jednotlivých R-skupin nejsou nenáhodně rozprostřeny na chromosomových teritorií, ale formují na chromosomech klastry. Skupiny genu s podobnou kinetikou regulace tedy můžeme najít na chromosomech blízko sebe. In the present study, a high density-microarrays of human cDNA containing 19,000 genetic elements were used to search for differences in gene expression of human promyelic leukaemia cell line HL-60 during monocyte (MD) and granulocyte differentiation (GD). For differentiation to monocytes (granulocytes), the TPA, 12-O-tetradecanoylphorbol-D-acetate (DMSO) were used, respectively. A total number of 4625 (4760) genes were found to be regulated during MD (GD). The genes have been divided into groups according to their kinetics of regulation (R-groups). The genes of the same group are not distributed randomly throughout the genome but form clusters on chromosomes (R-clusters). Thus, functionally interconnected genes are frequently localized near to each other on the DNA molecule. In the present study, a high density-microarrays of human cDNA containing 19,000 genetic elements were used to search for differences in gene expression of human promyelic leukaemia cell line HL-60 during monocyte (MD) and granulocyte differentiation (GD). For differentiation to monocytes (granulocytes), the TPA, 12-O-tetradecanoylphorbol-D-acetate (DMSO) were used, respectively. A total number of 4625 (4760) genes were found to be regulated during MD (GD). The genes have been divided into groups according to their kinetics of regulation (R-groups). The genes of the same group are not distributed randomly throughout the genome but form clusters on chromosomes (R-clusters). Thus, functionally interconnected genes are frequently localized near to each other on the DNA molecule.
dcterms:title
Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells Klastrování genů s podobným regulačním mechanismem během monocytární a garanulocytární diferenciace buněk HL-60 Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells
skos:prefLabel
Klastrování genů s podobným regulačním mechanismem během monocytární a garanulocytární diferenciace buněk HL-60 Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells
skos:notation
RIV/68081707:_____/04:00108489!RIV/2005/AV0/A17005/N
n3:strany
38;43
n3:aktivita
n10:P n10:Z
n3:aktivity
P(1A8241), P(GP301/04/P136), Z(AV0Z5004920), Z(MSM 143300002)
n3:dodaniDat
n7:2005
n3:domaciTvurceVysledku
n9:4873130 n9:8491313
n3:druhVysledku
n21:D
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
557919
n3:idVysledku
RIV/68081707:_____/04:00108489
n3:jazykVysledku
n5:eng
n3:klicovaSlova
gene expression; leukaemia cell line HL60; cDNA
n3:klicoveSlovo
n12:leukaemia%20cell%20line%20HL60 n12:gene%20expression n12:cDNA
n3:kontrolniKodProRIV
[729E0B245DC0]
n3:mistoKonaniAkce
Brno
n3:mistoVydani
Brno
n3:nazevZdroje
Biophysics of the Genome: Proceedings of the Workshop Held at Brno
n3:obor
n8:BO
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
8
n3:projekt
n15:GP301%2F04%2FP136 n15:1A8241
n3:rokUplatneniVysledku
n7:2004
n3:tvurceVysledku
Bártová, Eva Svoboda, Z. Faltýsková, E. Kozubek, M. Pavlík, T. Kozubek, Stanislav Krontorád, P. Koutná, I.
n3:typAkce
n16:WRD
n3:zahajeniAkce
2004-10-12+02:00
n3:zamer
n17:MSM%20143300002 n17:AV0Z5004920
s:numberOfPages
6
n19:hasPublisher
Masarykova univerzita v Brně
n18:isbn
80-210-3560-9