This HTML5 document contains 50 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n13http://linked.opendata.cz/resource/domain/vavai/projekt/
n10http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n11http://linked.opendata.cz/ontology/domain/vavai/
n17http://linked.opendata.cz/resource/domain/vavai/zamer/
n14http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F68081707%3A_____%2F04%3A00104704%21RIV%2F2005%2FAV0%2FA17005%2FN/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n8http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n15http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n9http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n5http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F04%3A00104704%21RIV%2F2005%2FAV0%2FA17005%2FN
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Bylo zjištěno, že sada PtII komplexů obecného složení [a3PtC]2+, cis-[a2PtC(OH)]2+, cis-[a2PtC2]2+ a trans-[a2PtCL]n+ (s a = NH3 nebo a3 = dien; C = 1-metyl-cytosin nebo 1,5-dimetylcytosin; L = C nebo jiná báze) ve vodném prostředí podstupuje hydrolytickou deaminaci. Mechanismus deaminační reakce byl objasněn pomocí DFT výpočtů a verifikován pomocí referenčních výpočtů na úrovni CCSD(T). Výsledky výpočtů naznačují, že kov na pozici N3 cytosinu slouží jako Lewisova kyselina a zprostředkovává nukleofilní atak externí OH-skupiny na pozici C4. A series of cationic PtII complexes of general composition [a3PtC]2+, cis-[a2PtC(OH)]2+, cis-[a2PtC2]2+ and trans-[a2PtCL]n+ (with a = NH3 or a3 = dien; C = 1-methyl-cytosine or 1,5-dimethylcytosine; L = C or other base) has been found to undergo hydrolytic deamination in aqueous solution. The mechanism of the deamination reaction has been enlightened applying DFT (Density Functional Theory) calculations and verified with reference computations at CCSD(T) level of theory. The results of these calculations suggest that the metal at N3 of the cytosine nucleophile acts as a Lewis acid and facilitates the nucleophilic attack of external OH- at the C4 position. A series of cationic PtII complexes of general composition [a3PtC]2+, cis-[a2PtC(OH)]2+, cis-[a2PtC2]2+ and trans-[a2PtCL]n+ (with a = NH3 or a3 = dien; C = 1-methyl-cytosine or 1,5-dimethylcytosine; L = C or other base) has been found to undergo hydrolytic deamination in aqueous solution. The mechanism of the deamination reaction has been enlightened applying DFT (Density Functional Theory) calculations and verified with reference computations at CCSD(T) level of theory. The results of these calculations suggest that the metal at N3 of the cytosine nucleophile acts as a Lewis acid and facilitates the nucleophilic attack of external OH- at the C4 position.
dcterms:title
Metal-mediated deamination of cytosine: experiment and DFT calculations Metal-mediated deamination of cytosine: experiment and DFT calculations Deaminace cytosinu pomocí kovů: experiment a výpočty DFT
skos:prefLabel
Deaminace cytosinu pomocí kovů: experiment a výpočty DFT Metal-mediated deamination of cytosine: experiment and DFT calculations Metal-mediated deamination of cytosine: experiment and DFT calculations
skos:notation
RIV/68081707:_____/04:00104704!RIV/2005/AV0/A17005/N
n3:strany
5396;5399
n3:aktivita
n9:Z n9:P
n3:aktivity
P(LN00A016), Z(AV0Z5004920)
n3:cisloPeriodika
40
n3:dodaniDat
n5:2005
n3:domaciTvurceVysledku
n10:3223779 n10:5279909
n3:druhVysledku
n16:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
573053
n3:idVysledku
RIV/68081707:_____/04:00104704
n3:jazykVysledku
n15:eng
n3:klicovaSlova
cytosine; deamination; density functional calculations
n3:klicoveSlovo
n4:density%20functional%20calculations n4:deamination n4:cytosine
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[3B11C7A627A0]
n3:nazevZdroje
Angewandte Chemie-International Edition
n3:obor
n18:BO
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
8
n3:projekt
n13:LN00A016
n3:rokUplatneniVysledku
n5:2004
n3:svazekPeriodika
43
n3:tvurceVysledku
Sanz Miguel, P. J. Sodupe, M. Šponer, Judit Erika Erxleben, A. Krumm, M. Rodríguez-Santiago, L. Šponer, Jiří Lippert, B.
n3:zamer
n17:AV0Z5004920
s:issn
1433-7851
s:numberOfPages
4