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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F04%3A00104667%21RIV%2F2005%2FAV0%2FA17005%2FN
rdf:type
n3:Vysledek skos:Concept
dcterms:description
A group of heterocyclic aromatic compounds, dinaphthofurans (DNFs), recently have been identified as potentially significant contaminants in freshwater sediments. In the present study, a battery of in vitro assays was used for detection of toxic effects of DNFs that are potentially associated with endocrine disruption and tumor promotion. Dinaphthofurans were found to act as relatively potent inducers of aryl hydrocarbon receptor (AhR)-mediated activity in the chemical-activated luciferase reporter gene expression DR-CALUX assay. The relative AbR-inducing potencies of DNFs were similar or even higher than relative potencies of unsubstituted polycyclic aromatic hydrocarbons (PAHs), with dinaphtho[1,2-b;2'3'-d]furan being the most potent AhR agonist. A group of heterocyclic aromatic compounds, dinaphthofurans (DNFs), recently have been identified as potentially significant contaminants in freshwater sediments. In the present study, a battery of in vitro assays was used for detection of toxic effects of DNFs that are potentially associated with endocrine disruption and tumor promotion. Dinaphthofurans were found to act as relatively potent inducers of aryl hydrocarbon receptor (AhR)-mediated activity in the chemical-activated luciferase reporter gene expression DR-CALUX assay. The relative AbR-inducing potencies of DNFs were similar or even higher than relative potencies of unsubstituted polycyclic aromatic hydrocarbons (PAHs), with dinaphtho[1,2-b;2'3'-d]furan being the most potent AhR agonist. Skupina heterocyklických aromatických sloučenin dinaftofuranů (DNF) byla nedávno identifikována jako potenciální kontaminanty sladkovodních sedimentů. V této studii byla použita baterie in vitro testů k detekci toxických účinku DNF, které mohou být potenciálně spojeny s narušením endokrinní regulace a nádorovou promocí. Bylo zjištěno, že dinaftofurany mohou účinkovat jako relativně silné induktory aktivity zprostředkované receptorem pro aromatické uhlovodíky (AhR) a stimulují proliferaci kontaktně inhibovaných jaterních epiteliálních buněk potkana. Relativní schopnost DNF indukovat AhR byla podobná nebo dokonce vyšší než u nesubstituovaných polycyklických aromatických uhlovodíků (PAH), přičemž dinafto[1,2-b;2'3'-d]furan je nejsilnější agonista AhR. Některé DNF zároveň aktivovaly estrogenní receptor.
dcterms:title
Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans Aktivace receptoru pro aromatické uhlovodíky a estrogenního receptoru, a modulace buněčné proliferace dinaftofurany Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans
skos:prefLabel
Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans Aktivace receptoru pro aromatické uhlovodíky a estrogenního receptoru, a modulace buněčné proliferace dinaftofurany Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans
skos:notation
RIV/68081707:_____/04:00104667!RIV/2005/AV0/A17005/N
n4:strany
2214;2220
n4:aktivita
n5:Z n5:P
n4:aktivity
P(GA525/03/1527), Z(AV0Z5004920)
n4:cisloPeriodika
9
n4:dodaniDat
n8:2005
n4:domaciTvurceVysledku
n7:2301229 n7:7864574 n7:1706063
n4:druhVysledku
n11:J
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
567739
n4:idVysledku
RIV/68081707:_____/04:00104667
n4:jazykVysledku
n15:eng
n4:klicovaSlova
aryl hydrocarbon receptor-mediated activity; estrogenicity; intercellular communication inhibition
n4:klicoveSlovo
n10:intercellular%20communication%20inhibition n10:aryl%20hydrocarbon%20receptor-mediated%20activity n10:estrogenicity
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[3E8BBF6C086A]
n4:nazevZdroje
Environmental Toxicology and chemistry
n4:obor
n16:BO
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
7
n4:projekt
n14:GA525%2F03%2F1527
n4:rokUplatneniVysledku
n8:2004
n4:svazekPeriodika
23
n4:tvurceVysledku
Bláha, L. Plíšková, M. Chramostová, Kateřina Vondráček, Jan Kozubík, Alois Machala, M. Brack, W.
n4:zamer
n18:AV0Z5004920
s:issn
0730-7268
s:numberOfPages
7