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Statements

Subject Item
n2:RIV%2F68081707%3A_____%2F03%3A17033132%21RIV%2F2004%2FAV0%2FA17004%2FN
rdf:type
n15:Vysledek skos:Concept
dcterms:description
The stereochemistry of the dinuclear complex [((eta(6)-biphenyl)RuCl(en))(2)-(CH2)(6)](2+) (3, en = ethylenediamine) was elucidated by studies of the half unit [(eta(6)-biphenyl)RuCl(Et-en)](+) (2, where Et-en is Et(H)NCH2CH2NH2). The structures of the separated R*R-Ru*(N) and S*R-Ru*(N) diastereomers of 2 were determined by x-ray crystallography. X-ray and NMR studies showed that dynamic chiral recognition of quanine can lead to high diastereoselectivity of DNA binding. The dinuclear complex induced a large unwinding of plasmid DNA and effectively inhibited DNA-directed RNA synthesis in vitro. It gave rise to interstrand cross-links on plasmid DNA, and to 1,3-GG interstrand and 1,2-GG and 1,3-GTG intrastrand cross-links on site specifically ruthenated 20-mers. The concept of induced-fit recognition of DNA by organometallic complexes containing dynamic stereogenic centers via epimerization, intercalation, and cross-linking may be useful in the design of anticancer drugs. The stereochemistry of the dinuclear complex [((eta(6)-biphenyl)RuCl(en))(2)-(CH2)(6)](2+) (3, en = ethylenediamine) was elucidated by studies of the half unit [(eta(6)-biphenyl)RuCl(Et-en)](+) (2, where Et-en is Et(H)NCH2CH2NH2). The structures of the separated R*R-Ru*(N) and S*R-Ru*(N) diastereomers of 2 were determined by x-ray crystallography. X-ray and NMR studies showed that dynamic chiral recognition of quanine can lead to high diastereoselectivity of DNA binding. The dinuclear complex induced a large unwinding of plasmid DNA and effectively inhibited DNA-directed RNA synthesis in vitro. It gave rise to interstrand cross-links on plasmid DNA, and to 1,3-GG interstrand and 1,2-GG and 1,3-GTG intrastrand cross-links on site specifically ruthenated 20-mers. The concept of induced-fit recognition of DNA by organometallic complexes containing dynamic stereogenic centers via epimerization, intercalation, and cross-linking may be useful in the design of anticancer drugs.
dcterms:title
Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers.
skos:prefLabel
Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers.
skos:notation
RIV/68081707:_____/03:17033132!RIV/2004/AV0/A17004/N
n3:strany
14623;14628
n3:aktivita
n4:P n4:Z
n3:aktivity
P(GA305/01/0418), P(GA305/02/1552), P(IAA5004101), Z(AV0Z5004920)
n3:cisloPeriodika
25
n3:dodaniDat
n13:2004
n3:domaciTvurceVysledku
n14:5105307 n14:7988346
n3:druhVysledku
n17:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
610152
n3:idVysledku
RIV/68081707:_____/03:17033132
n3:jazykVysledku
n16:eng
n3:klicovaSlova
organometallic complexes; platinum; DNA
n3:klicoveSlovo
n6:platinum n6:organometallic%20complexes n6:DNA
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[8A7F9C0E4844]
n3:nazevZdroje
Proceedings of the National Academy of Sciences of the United States of America
n3:obor
n18:BO
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
10
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n7:IAA5004101 n7:GA305%2F01%2F0418 n7:GA305%2F02%2F1552
n3:rokUplatneniVysledku
n13:2003
n3:svazekPeriodika
100
n3:tvurceVysledku
Nováková, Olga Chen, H. Gould, R. Brabec, Viktor Parsons, S. Bella, J. Sadler, P. J. Wang, F. Dawson, A. Parkinson, J. A.
n3:zamer
n5:AV0Z5004920
s:issn
0027-8424
s:numberOfPages
6