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Statements

Subject Item
n2:RIV%2F67985939%3A_____%2F12%3A00436173%21RIV15-GA0-67985939
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Here is presented some of the first information on interactions of compounds produced by cyanobacteria and green algae with estrogen receptor signaling. Estrogenic potency of aqueous extracts and exudates (culture spent media with extracellular products) of seven species of cyanobacteria (10 different laboratory strains) and two algal species were assessed by use of in vitro trans-activation assays. Compounds produced by cyanobacteria and algae, and in particular those excreted from the cells, were estrogenic. Most exudates were estrogenic with potencies expressed at 50% of the maximum response under control of the estrogen receptor ranging from 0.2 to 7.2 ng 17 beta-estradiol (E-2) equivalents (EEQ)/L The greatest estrogenic potency was observed for exudates of Microcystis aerigunosa, a common species that forms water blooms. Aqueous extracts of both green algae, but only one species of cyanobacteria (Aphanizomenon gracile) elicited significant estrogenicity with EEQ ranging from 15 to 280 ng 17 beta-estradiol (E-2)/g dry weight. Scenedesmus quadricauda exudates and extracts of Aphanizomenon flos-aquae were antagonistic to the ER when coexposed to E2. The EEQ potency was not correlated with concentrations of cyanotoxins, such as microcystin and cylindrospermopsin, which suggests that the EEQ was comprised of other compounds. The study demonstrates some differences between the estrogenic potency of aqueous extracts prepared from the same species, but of different origin, while the effects of exudates were comparable within species. The observed estrogenic potencies are important namely in relation to the possible mass expansion of cyanobacteria and release of the active compounds into surrounding water. Here is presented some of the first information on interactions of compounds produced by cyanobacteria and green algae with estrogen receptor signaling. Estrogenic potency of aqueous extracts and exudates (culture spent media with extracellular products) of seven species of cyanobacteria (10 different laboratory strains) and two algal species were assessed by use of in vitro trans-activation assays. Compounds produced by cyanobacteria and algae, and in particular those excreted from the cells, were estrogenic. Most exudates were estrogenic with potencies expressed at 50% of the maximum response under control of the estrogen receptor ranging from 0.2 to 7.2 ng 17 beta-estradiol (E-2) equivalents (EEQ)/L The greatest estrogenic potency was observed for exudates of Microcystis aerigunosa, a common species that forms water blooms. Aqueous extracts of both green algae, but only one species of cyanobacteria (Aphanizomenon gracile) elicited significant estrogenicity with EEQ ranging from 15 to 280 ng 17 beta-estradiol (E-2)/g dry weight. Scenedesmus quadricauda exudates and extracts of Aphanizomenon flos-aquae were antagonistic to the ER when coexposed to E2. The EEQ potency was not correlated with concentrations of cyanotoxins, such as microcystin and cylindrospermopsin, which suggests that the EEQ was comprised of other compounds. The study demonstrates some differences between the estrogenic potency of aqueous extracts prepared from the same species, but of different origin, while the effects of exudates were comparable within species. The observed estrogenic potencies are important namely in relation to the possible mass expansion of cyanobacteria and release of the active compounds into surrounding water.
dcterms:title
Estrogenic activity in extracts and exudates of cyanobacteria and green algae Estrogenic activity in extracts and exudates of cyanobacteria and green algae
skos:prefLabel
Estrogenic activity in extracts and exudates of cyanobacteria and green algae Estrogenic activity in extracts and exudates of cyanobacteria and green algae
skos:notation
RIV/67985939:_____/12:00436173!RIV15-GA0-67985939
n3:aktivita
n17:I n17:S n17:P
n3:aktivity
I, P(2B08036), P(ED0001/01/01), P(GA524/08/0496), S
n3:cisloPeriodika
1
n3:dodaniDat
n13:2015
n3:domaciTvurceVysledku
n4:4982800
n3:druhVysledku
n15:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
134818
n3:idVysledku
RIV/67985939:_____/12:00436173
n3:jazykVysledku
n12:eng
n3:klicovaSlova
cyanobacteria; endocrine disruption; estrogenicity; algae; phytoplankton
n3:klicoveSlovo
n8:endocrine%20disruption n8:cyanobacteria n8:algae n8:estrogenicity n8:phytoplankton
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[40C5BF8A7E56]
n3:nazevZdroje
Environment International
n3:obor
n14:EF
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n6:GA524%2F08%2F0496 n6:2B08036 n6:ED0001%2F01%2F01
n3:rokUplatneniVysledku
n13:2012
n3:svazekPeriodika
39
n3:tvurceVysledku
Sychrová, E. Štěpánkdová, T. Giesy, J. P. Hilscherová, K. Nováková, K. Bláha, Luděk
n3:wos
000300129100018
s:issn
0160-4120
s:numberOfPages
7
n16:doi
10.1016/j.envint.2011.10.004