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Statements

Subject Item
n2:RIV%2F67985939%3A_____%2F11%3A00369361%21RIV12-AV0-67985939
rdf:type
n13:Vysledek skos:Concept
dcterms:description
An algal extracellular biopolymer (over 8.5 105 Da) composed of carbohydrates (52%) and protein (13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer contained xylose and its 3-O- and 4-O-methyl derivatives (63%), galactose (12%), glucuronic acid (11–12%), glucose (5%), rhamnose (4%), fucose (3–4%) and low content of others accompaning sugars. When tested on the citric acid-induced cough and reactivity of airways smooth muscle in vivo in the test system guinea pigs, this biopolymer assigned a significant cough suppressing effect. The reactivity of airways smooth muscle was not affected indicating that expectoration effect was not suppressed by biopolymer application, which is important from the pharmacological point of view. An algal extracellular biopolymer (over 8.5 105 Da) composed of carbohydrates (52%) and protein (13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer contained xylose and its 3-O- and 4-O-methyl derivatives (63%), galactose (12%), glucuronic acid (11–12%), glucose (5%), rhamnose (4%), fucose (3–4%) and low content of others accompaning sugars. When tested on the citric acid-induced cough and reactivity of airways smooth muscle in vivo in the test system guinea pigs, this biopolymer assigned a significant cough suppressing effect. The reactivity of airways smooth muscle was not affected indicating that expectoration effect was not suppressed by biopolymer application, which is important from the pharmacological point of view.
dcterms:title
Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex
skos:prefLabel
Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex
skos:notation
RIV/67985939:_____/11:00369361!RIV12-AV0-67985939
n13:predkladatel
n18:ico%3A67985939
n3:aktivita
n17:P n17:Z
n3:aktivity
P(1M0571), Z(AV0Z60050516)
n3:cisloPeriodika
4
n3:dodaniDat
n5:2012
n3:domaciTvurceVysledku
n8:3512797 n8:9185720
n3:druhVysledku
n16:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
204688
n3:idVysledku
RIV/67985939:_____/11:00369361
n3:jazykVysledku
n11:eng
n3:klicovaSlova
Rhodella griesea; proteoglykan; cough
n3:klicoveSlovo
n12:proteoglykan n12:Rhodella%20griesea n12:cough
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[24907AE7D68A]
n3:nazevZdroje
International Journal of Biological Macromolecules
n3:obor
n6:EF
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
10
n3:projekt
n7:1M0571
n3:rokUplatneniVysledku
n5:2011
n3:svazekPeriodika
49
n3:tvurceVysledku
Turjan, J. Lukavský, Jaromír Jureček, Ľ. Cepák, Vladislav Ray, B. Flešková, D. Breierová, E. Nosál´ová, G. Capek, P. Hindák, F.
n3:wos
000296937200028
n3:zamer
n19:AV0Z60050516
s:issn
0141-8130
s:numberOfPages
5
n9:doi
10.1016/j.ijbiomac.2011.08.029