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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F12%3A00390656%21RIV13-AV0-67985904
rdf:type
skos:Concept n8:Vysledek
dcterms:description
Mutation in the ubiquitously expressed cytoplasmic superoxide dismutase (SOD1) causes an inherited form of Amyotrophic Lateral Sclerosis (ALS). Mutant synthesis in motor neurons drives disease onset and early disease progression. Previous experimental studies have shown that spinal grafting of human fetal spinal neural stem cells (hNSCs) into the lumbar spinal cord of SOD1(G93A) rats leads to a moderate therapeutical effect as evidenced by local alpha-motoneuron sparing and extension of lifespan. The aim of the present study was to analyze the degree of therapeutical effect of hNSCs once grafted into the lumbar spinal ventral horn in presymptomatic immunosuppressed SOD1(G93A) rats and to assess the presence and functional integrity of the descending motor system in symptomatic SOD1(G93A) animals. Mutation in the ubiquitously expressed cytoplasmic superoxide dismutase (SOD1) causes an inherited form of Amyotrophic Lateral Sclerosis (ALS). Mutant synthesis in motor neurons drives disease onset and early disease progression. Previous experimental studies have shown that spinal grafting of human fetal spinal neural stem cells (hNSCs) into the lumbar spinal cord of SOD1(G93A) rats leads to a moderate therapeutical effect as evidenced by local alpha-motoneuron sparing and extension of lifespan. The aim of the present study was to analyze the degree of therapeutical effect of hNSCs once grafted into the lumbar spinal ventral horn in presymptomatic immunosuppressed SOD1(G93A) rats and to assess the presence and functional integrity of the descending motor system in symptomatic SOD1(G93A) animals.
dcterms:title
Human Neural Stem Cell Replacement Therapy for Amyotrophic Lateral Sclerosis by Spinal Transplantation Human Neural Stem Cell Replacement Therapy for Amyotrophic Lateral Sclerosis by Spinal Transplantation
skos:prefLabel
Human Neural Stem Cell Replacement Therapy for Amyotrophic Lateral Sclerosis by Spinal Transplantation Human Neural Stem Cell Replacement Therapy for Amyotrophic Lateral Sclerosis by Spinal Transplantation
skos:notation
RIV/67985904:_____/12:00390656!RIV13-AV0-67985904
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n9:ico%3A67985904
n3:aktivita
n18:I
n3:aktivity
I
n3:cisloPeriodika
8
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n13:8103283
n3:druhVysledku
n17:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
139876
n3:idVysledku
RIV/67985904:_____/12:00390656
n3:jazykVysledku
n14:eng
n3:klicovaSlova
central nervous system; SOD 1 transgenic rats; motor neurons
n3:klicoveSlovo
n7:SOD%201%20transgenic%20rats n7:motor%20neurons n7:central%20nervous%20system
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[444825D2C94F]
n3:nazevZdroje
PLoS ONE
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
12
n3:rokUplatneniVysledku
n12:2012
n3:svazekPeriodika
7
n3:tvurceVysledku
Marsala, M. Hruška-Plocháň, Marian Santucci, C. Hefferan, M. P. Navarro, R. Cleveland, D. W. Feldman, E. Johe, K. Galik, J. Sekerková, G. Kakinohana, O. Marsala, S.
n3:wos
000307733800022
s:issn
1932-6203
s:numberOfPages
14
n15:doi
10.1371/journal.pone.0042614