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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F12%3A00387180%21RIV13-AV0-67985904
rdf:type
skos:Concept n16:Vysledek
dcterms:description
OBJECTIVES: The methylenetetrahydrofolate reductase (MTHFR) enzyme activity plays an important role in the metabolism of folate within methionine-homocysteine pathway and, consequently, in the development of vascular diseases. The C677T polymorphism (rs1801133) of the MTHFR gene affects the MTHFR activity, modifies the homocysteine plasma concentration and, among others, increases the risks for idiopathic male infertility, including erectile dysfunction (ED). As this sexual dysfunction is related to sex hormone levels, we investigated a possible relationship between the C677T polymorphism of the MTHFR gene and plasma concentrations of follicle-stimulating hormone (FSH) as well as luteinizing hormone (LH) in male patients with ED. METHODS: We conducted our study on 90 healthy men with ED between the age of 32 and 61 (mean age was 51.1 +/- 11.5) years. The subjects were genotyped and their FSH and LH plasma levels were analysed. RESULTS: The analysis results of ED patients and their genotypes of the MTHFR gene did not provide evidence supporting any causal association of T allele in CT and TT genotypes with studied clinical parameters. However, we found that patients with the CC genotype had significantly higher plasma levels of LH than patients with the CT and/or TT genotypes. CONCLUSIONS: Our observations suggest that the C677T polymorphism of MTHFR gene has no direct relationship to erectile dysfunction, but does exhibit a relationship between this rs1801133 polymorphism and plasma LH concentrations. OBJECTIVES: The methylenetetrahydrofolate reductase (MTHFR) enzyme activity plays an important role in the metabolism of folate within methionine-homocysteine pathway and, consequently, in the development of vascular diseases. The C677T polymorphism (rs1801133) of the MTHFR gene affects the MTHFR activity, modifies the homocysteine plasma concentration and, among others, increases the risks for idiopathic male infertility, including erectile dysfunction (ED). As this sexual dysfunction is related to sex hormone levels, we investigated a possible relationship between the C677T polymorphism of the MTHFR gene and plasma concentrations of follicle-stimulating hormone (FSH) as well as luteinizing hormone (LH) in male patients with ED. METHODS: We conducted our study on 90 healthy men with ED between the age of 32 and 61 (mean age was 51.1 +/- 11.5) years. The subjects were genotyped and their FSH and LH plasma levels were analysed. RESULTS: The analysis results of ED patients and their genotypes of the MTHFR gene did not provide evidence supporting any causal association of T allele in CT and TT genotypes with studied clinical parameters. However, we found that patients with the CC genotype had significantly higher plasma levels of LH than patients with the CT and/or TT genotypes. CONCLUSIONS: Our observations suggest that the C677T polymorphism of MTHFR gene has no direct relationship to erectile dysfunction, but does exhibit a relationship between this rs1801133 polymorphism and plasma LH concentrations.
dcterms:title
The relationship between the C677T polymorphism of the MTHFR gene and serum levels of luteinizing hormone in males with erectile dysfunction The relationship between the C677T polymorphism of the MTHFR gene and serum levels of luteinizing hormone in males with erectile dysfunction
skos:prefLabel
The relationship between the C677T polymorphism of the MTHFR gene and serum levels of luteinizing hormone in males with erectile dysfunction The relationship between the C677T polymorphism of the MTHFR gene and serum levels of luteinizing hormone in males with erectile dysfunction
skos:notation
RIV/67985904:_____/12:00387180!RIV13-AV0-67985904
n16:predkladatel
n17:ico%3A67985904
n3:aktivita
n9:P n9:I
n3:aktivity
I, P(NT11152)
n3:cisloPeriodika
5
n3:dodaniDat
n8:2013
n3:domaciTvurceVysledku
n7:3881652
n3:druhVysledku
n4:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
164846
n3:idVysledku
RIV/67985904:_____/12:00387180
n3:jazykVysledku
n13:eng
n3:klicovaSlova
MTHFR; C677T polymorphism; follicle-stimulating hormone
n3:klicoveSlovo
n6:MTHFR n6:follicle-stimulating%20hormone n6:C677T%20polymorphism
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[33032A0B09AC]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n14:FB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n11:NT11152
n3:rokUplatneniVysledku
n8:2012
n3:svazekPeriodika
33
n3:tvurceVysledku
Šerý, Omar Šrámková, T. Šťastný, F. Lochman, J. Klempová, J. Khan, N. A.
n3:wos
000311470400006
s:issn
0172-780X
s:numberOfPages
6