This HTML5 document contains 52 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n7http://linked.opendata.cz/resource/domain/vavai/projekt/
n5http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n10http://linked.opendata.cz/resource/domain/vavai/subjekt/
n9http://linked.opendata.cz/ontology/domain/vavai/
n18http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n8http://bibframe.org/vocab/
n19http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F67985904%3A_____%2F12%3A00380411%21RIV13-GA0-67985904/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n20http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n14http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n6http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F12%3A00380411%21RIV13-GA0-67985904
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Chromosome segregation errors are highly frequent in mammalian female meiosis, and their incidence gradually increases with maternal age. The fate of aneuploid eggs is obviously dependent on the stringency of mechanisms for detecting unattached or repairing incorrectly attached kinetochores. In case of their failure, the newly formed embryo will inherit the impaired set of chromosomes, which will have severe consequences for its further development. Whether spindle assembly checkpoint (SAC) in oocytes is capable of arresting cell cycle progression in response to unaligned kinetochores was discussed for a long time. It is known that abolishing SAC increases frequency of chromosome segregation errors and causes precocious entry into anaphase; SAC, therefore, seems to be essential for normal chromosome segregation in meiosis I. However, it was also reported that for anaphase-promoting complex (APC) activation, which is a prerequisite for entering anaphase; alignment of only a critical mass of kinetochores on equatorial plane is sufficient. This indicates that the function of SAC and of cooperating chromosome attachment correction mechanisms in oocytes is different from somatic cells. To analyze this phenomenon, we used live cell confocal microscopy to monitor chromosome movements, spindle formation, APC activation and polar body extrusion (PBE) simultaneously in individual oocytes at various time points during first meiotic division. Our results, using oocytes from aged animals and interspecific crosses, demonstrate that multiple unaligned kinetochores and severe congression defects are tolerated at the metaphase to anaphase transition, although such cells retain sensitivity to nocodazole... Chromosome segregation errors are highly frequent in mammalian female meiosis, and their incidence gradually increases with maternal age. The fate of aneuploid eggs is obviously dependent on the stringency of mechanisms for detecting unattached or repairing incorrectly attached kinetochores. In case of their failure, the newly formed embryo will inherit the impaired set of chromosomes, which will have severe consequences for its further development. Whether spindle assembly checkpoint (SAC) in oocytes is capable of arresting cell cycle progression in response to unaligned kinetochores was discussed for a long time. It is known that abolishing SAC increases frequency of chromosome segregation errors and causes precocious entry into anaphase; SAC, therefore, seems to be essential for normal chromosome segregation in meiosis I. However, it was also reported that for anaphase-promoting complex (APC) activation, which is a prerequisite for entering anaphase; alignment of only a critical mass of kinetochores on equatorial plane is sufficient. This indicates that the function of SAC and of cooperating chromosome attachment correction mechanisms in oocytes is different from somatic cells. To analyze this phenomenon, we used live cell confocal microscopy to monitor chromosome movements, spindle formation, APC activation and polar body extrusion (PBE) simultaneously in individual oocytes at various time points during first meiotic division. Our results, using oocytes from aged animals and interspecific crosses, demonstrate that multiple unaligned kinetochores and severe congression defects are tolerated at the metaphase to anaphase transition, although such cells retain sensitivity to nocodazole...
dcterms:title
Lack of response to unaligned chromosomes in mammalian female gametes Lack of response to unaligned chromosomes in mammalian female gametes
skos:prefLabel
Lack of response to unaligned chromosomes in mammalian female gametes Lack of response to unaligned chromosomes in mammalian female gametes
skos:notation
RIV/67985904:_____/12:00380411!RIV13-GA0-67985904
n9:predkladatel
n10:ico%3A67985904
n3:aktivita
n17:P n17:Z
n3:aktivity
P(ED1.1.00/02.0068), P(GA523/09/0743), P(GAP502/10/0944), P(GD204/09/H084), Z(AV0Z50450515)
n3:cisloPeriodika
16
n3:dodaniDat
n6:2013
n3:domaciTvurceVysledku
n5:2188554 n5:1114921 n5:4607252 n5:2200074 Danylevska, Anna
n3:druhVysledku
n15:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
146340
n3:idVysledku
RIV/67985904:_____/12:00380411
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Anaphase; Aneuploidy; Cell cycle
n3:klicoveSlovo
n4:Aneuploidy n4:Anaphase n4:Cell%20cycle
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[7BD930489EDB]
n3:nazevZdroje
Cell Cycle
n3:obor
n13:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n7:ED1.1.00%2F02.0068 n7:GAP502%2F10%2F0944 n7:GA523%2F09%2F0743 n7:GD204%2F09%2FH084
n3:rokUplatneniVysledku
n6:2012
n3:svazekPeriodika
11
n3:tvurceVysledku
Anger, Martin Šebestová, Jaroslava Kubelka, Michal Nováková, Lucia Danylevska, Anna
n3:wos
000308004000019
n3:zamer
n18:AV0Z50450515
s:issn
1538-4101
s:numberOfPages
8
n8:doi
10.4161/cc.21398