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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F12%3A00377169%21RIV13-AV0-67985904
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Loss of GABA-mediated pre-synaptic inhibition after spinal injury plays a key role in the progressive increase in spinal reflexes and the appearance of spasticity. Clinical studies show that the use of baclofen (GABA(B) receptor agonist), while effective in modulating spasticity is associated with major side effects such as general sedation and progressive tolerance development. The goal of the present study was to assess if a combined therapy composed of spinal segment-specific upregulation of GAD65 (glutamate decarboxylase) gene once combined with systemic treatment with tiagabine (GABA uptake inhibitor) will lead to an antispasticity effect and whether such an effect will only be present in GAD65 gene over-expressing spinal segments. Loss of GABA-mediated pre-synaptic inhibition after spinal injury plays a key role in the progressive increase in spinal reflexes and the appearance of spasticity. Clinical studies show that the use of baclofen (GABA(B) receptor agonist), while effective in modulating spasticity is associated with major side effects such as general sedation and progressive tolerance development. The goal of the present study was to assess if a combined therapy composed of spinal segment-specific upregulation of GAD65 (glutamate decarboxylase) gene once combined with systemic treatment with tiagabine (GABA uptake inhibitor) will lead to an antispasticity effect and whether such an effect will only be present in GAD65 gene over-expressing spinal segments.
dcterms:title
Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity
skos:prefLabel
Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity Combinational Spinal GAD65 Gene Delivery and Systemic GABA-Mimetic Treatment for Modulation of Spasticity
skos:notation
RIV/67985904:_____/12:00377169!RIV13-AV0-67985904
n7:predkladatel
n11:ico%3A67985904
n3:aktivita
n4:Z
n3:aktivity
Z(AV0Z50450515)
n3:cisloPeriodika
1
n3:dodaniDat
n16:2013
n3:domaciTvurceVysledku
n5:5434505 n5:4536096 n5:1947788 n5:5297001
n3:druhVysledku
n12:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
127682
n3:idVysledku
RIV/67985904:_____/12:00377169
n3:jazykVysledku
n14:eng
n3:klicovaSlova
INTRATHECAL BACLOFEN; CORD-INJURY; UPTAKE INHIBITOR
n3:klicoveSlovo
n10:UPTAKE%20INHIBITOR n10:CORD-INJURY n10:INTRATHECAL%20BACLOFEN
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E1FFF8F2AD02]
n3:nazevZdroje
PLoS ONE
n3:obor
n18:FH
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
15
n3:rokUplatneniVysledku
n16:2012
n3:svazekPeriodika
7
n3:tvurceVysledku
Strnádel, Ján Hefferan, M. P. Juhásová, Jana Kakinohana, O. Motlík, Jan Galik, J. Juhás, Štefan Nejime, T. Lazar, P. Marsala, M. Marsala, S. Miyanohara, A. Vinay, L. Platoshyn, O. Kucharova, K.
n3:wos
000301570600059
n3:zamer
n6:AV0Z50450515
s:issn
1932-6203
s:numberOfPages
13
n17:doi
10.1371/journal.pone.0030561