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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F11%3A00377696%21RIV13-GA0-67985904
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Gametogenesis and fertilization are the key events in sexual reproduction. In the female, meiosis results in a large oocyte that is competent for fertilization and fundamental for the success of early embryonic development. Progression through meiosis is monitored by fine regulatory mechanisms. In this review, we focus on one of the most well-known regulatory elements, the E3 ligase APC/C, which mediates proteolytic degradation of a number of important substrates via the ubiquitin proteasome pathway (UPP). The UPP also indirectly regulates protein synthesis by affecting proteins involved in RNA metabolism, a process that is paramount for the transcriptionally silent oocyte. During the past few years, more evidence has accumulated to suggest that the UPP has an important role in zona pellucida penetration and gamete fusion in mammals. This review focuses on the function of the UPP in regulating oocyte meiotic maturation in mammals, with special attention to its role in chromosome segregation and polar body extrusion, its role in the acquisition of meiotic/developmental competence and recent advances in our understanding of the UPP role in fertilization. Gametogenesis and fertilization are the key events in sexual reproduction. In the female, meiosis results in a large oocyte that is competent for fertilization and fundamental for the success of early embryonic development. Progression through meiosis is monitored by fine regulatory mechanisms. In this review, we focus on one of the most well-known regulatory elements, the E3 ligase APC/C, which mediates proteolytic degradation of a number of important substrates via the ubiquitin proteasome pathway (UPP). The UPP also indirectly regulates protein synthesis by affecting proteins involved in RNA metabolism, a process that is paramount for the transcriptionally silent oocyte. During the past few years, more evidence has accumulated to suggest that the UPP has an important role in zona pellucida penetration and gamete fusion in mammals. This review focuses on the function of the UPP in regulating oocyte meiotic maturation in mammals, with special attention to its role in chromosome segregation and polar body extrusion, its role in the acquisition of meiotic/developmental competence and recent advances in our understanding of the UPP role in fertilization.
dcterms:title
Proteasomal degradation of ubiquitinated proteins in oocyte meiosis and fertilization in mammals Proteasomal degradation of ubiquitinated proteins in oocyte meiosis and fertilization in mammals
skos:prefLabel
Proteasomal degradation of ubiquitinated proteins in oocyte meiosis and fertilization in mammals Proteasomal degradation of ubiquitinated proteins in oocyte meiosis and fertilization in mammals
skos:notation
RIV/67985904:_____/11:00377696!RIV13-GA0-67985904
n14:predkladatel
n15:ico%3A67985904
n3:aktivita
n6:P n6:Z
n3:aktivity
P(GAP502/10/0944), P(GD204/09/H084), Z(AV0Z50450515)
n3:cisloPeriodika
1
n3:dodaniDat
n5:2013
n3:domaciTvurceVysledku
n11:3064468 n11:1114921 n11:6275532
n3:druhVysledku
n18:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
224795
n3:idVysledku
RIV/67985904:_____/11:00377696
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Oocyte; Proteasome; Meiosis
n3:klicoveSlovo
n4:Meiosis n4:Proteasome n4:Oocyte
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[F3370C1EE672]
n3:nazevZdroje
Cell and Tissue Research
n3:obor
n20:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n12:GD204%2F09%2FH084 n12:GAP502%2F10%2F0944
n3:rokUplatneniVysledku
n5:2011
n3:svazekPeriodika
346
n3:tvurceVysledku
Karabínová, Pavla Kubelka, Michal Šušor, Andrej
n3:wos
000297123200001
n3:zamer
n13:AV0Z50450515
s:issn
0302-766X
s:numberOfPages
9
n9:doi
10.1007/s00441-011-1235-1