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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F11%3A00368272%21RIV12-AV0-67985904
rdf:type
n4:Vysledek skos:Concept
dcterms:description
The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis. The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis.
dcterms:title
Expression and characterization of c-Myb in prenatal odontogenesis Expression and characterization of c-Myb in prenatal odontogenesis
skos:prefLabel
Expression and characterization of c-Myb in prenatal odontogenesis Expression and characterization of c-Myb in prenatal odontogenesis
skos:notation
RIV/67985904:_____/11:00368272!RIV12-AV0-67985904
n4:predkladatel
n10:ico%3A67985904
n5:aktivita
n13:P n13:Z
n5:aktivity
P(GAP304/11/1418), P(GC524/08/J032), P(GP304/08/P289), P(KJB500450802), Z(AV0Z50450515), Z(MSM0021622415)
n5:cisloPeriodika
6
n5:dodaniDat
n6:2012
n5:domaciTvurceVysledku
n11:9861165 n11:4002032 n11:3580695 n11:9721436
n5:druhVysledku
n15:J
n5:duvernostUdaju
n18:S
n5:entitaPredkladatele
n19:predkladatel
n5:idSjednocenehoVysledku
199014
n5:idVysledku
RIV/67985904:_____/11:00368272
n5:jazykVysledku
n20:eng
n5:klicovaSlova
morphogenesis; mouse; Myb
n5:klicoveSlovo
n14:Myb n14:morphogenesis n14:mouse
n5:kodStatuVydavatele
JP - Japonsko
n5:kontrolniKodProRIV
[2F0F9D72E12F]
n5:nazevZdroje
Development Growth & Differentiation
n5:obor
n17:FF
n5:pocetDomacichTvurcuVysledku
4
n5:pocetTvurcuVysledku
8
n5:projekt
n7:KJB500450802 n7:GAP304%2F11%2F1418 n7:GC524%2F08%2FJ032 n7:GP304%2F08%2FP289
n5:rokUplatneniVysledku
n6:2011
n5:svazekPeriodika
53
n5:tvurceVysledku
Bender, T. P. Janečková, Eva Lungová, V. Šmarda, J. Tucker, A. S. Buchtová, Marcela Balková, Simona Matalová, Eva
n5:wos
000293902200004
n5:zamer
n16:AV0Z50450515 n16:MSM0021622415
s:issn
0012-1592
s:numberOfPages
11
n3:doi
10.1111/j.1440-169X.2011.01287.x