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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F11%3A00365035%21RIV12-AV0-67985904
rdf:type
n8:Vysledek skos:Concept
dcterms:description
It is generally accepted that mammalian oocytes are frequently suffering from chromosome segregation errors during meiosis I, which have severe consequences, including pregnancy loss, developmental disorders and mental retardation. In a search for physiologically more relevant model than rodent oocytes to study this phenomenon, we have employed comparative genomic hybridization (CGH), combined with whole genome amplification (WGA), to study the frequency of aneuploidy in porcine oocytes, including rare cells obtained from aged animals. Using this method, we were able to analyze segregation pattern of each individual chromosome during meiosis I. In contrast to the previous reports where conventional methods, such as chromosome spreads or FISH, were used to estimate frequency of aneuploidy, our results presented here show, that the frequency of this phenomenon was overestimated in porcine oocytes. It is generally accepted that mammalian oocytes are frequently suffering from chromosome segregation errors during meiosis I, which have severe consequences, including pregnancy loss, developmental disorders and mental retardation. In a search for physiologically more relevant model than rodent oocytes to study this phenomenon, we have employed comparative genomic hybridization (CGH), combined with whole genome amplification (WGA), to study the frequency of aneuploidy in porcine oocytes, including rare cells obtained from aged animals. Using this method, we were able to analyze segregation pattern of each individual chromosome during meiosis I. In contrast to the previous reports where conventional methods, such as chromosome spreads or FISH, were used to estimate frequency of aneuploidy, our results presented here show, that the frequency of this phenomenon was overestimated in porcine oocytes.
dcterms:title
Frequency of aneuploidy related to age in porcine oocytes Frequency of aneuploidy related to age in porcine oocytes
skos:prefLabel
Frequency of aneuploidy related to age in porcine oocytes Frequency of aneuploidy related to age in porcine oocytes
skos:notation
RIV/67985904:_____/11:00365035!RIV12-AV0-67985904
n8:predkladatel
n19:ico%3A67985904
n4:aktivita
n11:Z n11:P
n4:aktivity
P(GA523/09/0743), P(IAA501620801), Z(AV0Z50450515)
n4:cisloPeriodika
4
n4:dodaniDat
n12:2012
n4:domaciTvurceVysledku
n5:1114921 n5:2188554 n5:7205120 n5:5434505
n4:druhVysledku
n13:J
n4:duvernostUdaju
n7:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
200391
n4:idVysledku
RIV/67985904:_____/11:00365035
n4:jazykVysledku
n17:eng
n4:klicovaSlova
porcine; oocytes; aneuploidy
n4:klicoveSlovo
n16:aneuploidy n16:porcine n16:oocytes
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[7B65674682E5]
n4:nazevZdroje
PLoS ONE
n4:obor
n20:EE
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
8
n4:projekt
n10:IAA501620801 n10:GA523%2F09%2F0743
n4:rokUplatneniVysledku
n12:2011
n4:svazekPeriodika
6
n4:tvurceVysledku
Horňák, M. Kubelka, Michal Jeseta, M. Musilová, P. Anger, Martin Rubeš, J. Pavlok, Antonín Motlík, Jan
n4:wos
000290019400013
n4:zamer
n18:AV0Z50450515
s:issn
1932-6203
s:numberOfPages
5
n14:doi
10.1371/journal.pone.0018892