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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F11%3A00360511%21RIV12-AV0-67985904
rdf:type
n6:Vysledek skos:Concept
dcterms:description
The maturation of vertebrate oocyte into haploid gamete, the egg, consists of two specialized asymmetric cell divisions with no intervening S-phase. Ran GTPase has an essential role in relaying the active role of chromosomes in their own segregation by the meiotic process. In addition to its conserved role as a key regulator of macromolecular transport between nucleus and cytoplasm, Ran has important functions during cell division, including in mitotic spindle assembly and in the assembly of nuclear envelope at the exit from mitosis. The cellular functions of Ran are mediated by RanGTP interactions with nuclear transport receptors (NTRs) related to importin b and depend on the existence of chromosome-centered RanGTP gradient. Live imaging with FRET biosensors indeed revealed the existence of RanGTP gradient throughout mouse oocyte maturation. The maturation of vertebrate oocyte into haploid gamete, the egg, consists of two specialized asymmetric cell divisions with no intervening S-phase. Ran GTPase has an essential role in relaying the active role of chromosomes in their own segregation by the meiotic process. In addition to its conserved role as a key regulator of macromolecular transport between nucleus and cytoplasm, Ran has important functions during cell division, including in mitotic spindle assembly and in the assembly of nuclear envelope at the exit from mitosis. The cellular functions of Ran are mediated by RanGTP interactions with nuclear transport receptors (NTRs) related to importin b and depend on the existence of chromosome-centered RanGTP gradient. Live imaging with FRET biosensors indeed revealed the existence of RanGTP gradient throughout mouse oocyte maturation.
dcterms:title
The Role of RanGTP Gradient in Vertebrate Oocyte Maturation The Role of RanGTP Gradient in Vertebrate Oocyte Maturation
skos:prefLabel
The Role of RanGTP Gradient in Vertebrate Oocyte Maturation The Role of RanGTP Gradient in Vertebrate Oocyte Maturation
skos:notation
RIV/67985904:_____/11:00360511!RIV12-AV0-67985904
n6:predkladatel
n22:ico%3A67985904
n3:aktivita
n9:P n9:Z
n3:aktivity
P(GC301/09/J036), P(ME08030), Z(AV0Z50450515)
n3:dodaniDat
n16:2012
n3:domaciTvurceVysledku
n7:8523487 n7:5434505
n3:druhVysledku
n20:C
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
227499
n3:idVysledku
RIV/67985904:_____/11:00360511
n3:jazykVysledku
n5:eng
n3:klicovaSlova
RanGTP; Oocyte
n3:klicoveSlovo
n4:Oocyte n4:RanGTP
n3:kontrolniKodProRIV
[16D87DA2DAD0]
n3:mistoVydani
Heidelberg
n3:nazevZdroje
Results and Problems in Cell Differentiation
n3:obor
n11:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetStranKnihy
588
n3:pocetTvurcuVysledku
3
n3:projekt
n10:GC301%2F09%2FJ036 n10:ME08030
n3:rokUplatneniVysledku
n16:2011
n3:tvurceVysledku
Kalab, P. Šolc, Petr Motlík, Jan
n3:zamer
n12:AV0Z50450515
s:numberOfPages
33
n17:doi
10.1007/978-3-642-19065-0_12
n14:hasPublisher
Springer-Verlag
n21:isbn
978-3-642-19065-0