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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F11%3A00356673%21RIV11-MSM-67985904
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Within a mammalian organism, the interaction among cells both at short and long distances is mediated by soluble factors released by cells into the extracellular environment. The secreted proteins may involve extracellular matrix proteins, proteinases, growth factors, protein hormones, immunoregulatory cytokines, chemokines or other bioactive molecules that have a direct impact on target cell phenotype. Stem cells of mesenchymal, adipose, neural and embryonic origin, fibroblast feeder cells as well as primary isolates of astrocytes, endothelial and muscle cells have recently become targets of intensive secretome profiling with the search for proteins regulating cell survival, proliferation, differentiation or inflammatory response. Recent advances and challenges of the stem cell and primary cell secretome analysis together with the most relevant results are discussed in this review. Within a mammalian organism, the interaction among cells both at short and long distances is mediated by soluble factors released by cells into the extracellular environment. The secreted proteins may involve extracellular matrix proteins, proteinases, growth factors, protein hormones, immunoregulatory cytokines, chemokines or other bioactive molecules that have a direct impact on target cell phenotype. Stem cells of mesenchymal, adipose, neural and embryonic origin, fibroblast feeder cells as well as primary isolates of astrocytes, endothelial and muscle cells have recently become targets of intensive secretome profiling with the search for proteins regulating cell survival, proliferation, differentiation or inflammatory response. Recent advances and challenges of the stem cell and primary cell secretome analysis together with the most relevant results are discussed in this review.
dcterms:title
Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines
skos:prefLabel
Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines
skos:notation
RIV/67985904:_____/11:00356673!RIV11-MSM-67985904
n17:predkladatel
n19:ico%3A67985904
n4:aktivita
n18:Z n18:P
n4:aktivity
P(1M0538), P(ME10044), Z(AV0Z50450515)
n4:cisloPeriodika
-
n4:dodaniDat
n11:2011
n4:domaciTvurceVysledku
n12:6541186 n12:5434505 n12:1147633
n4:druhVysledku
n6:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
210634
n4:idVysledku
RIV/67985904:_____/11:00356673
n4:jazykVysledku
n9:eng
n4:klicovaSlova
cell biology; conditioned media; cytokine
n4:klicoveSlovo
n14:cell%20biology n14:cytokine n14:conditioned%20media
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[9497E297587B]
n4:nazevZdroje
Proteomics
n4:obor
n5:EB
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
4
n4:projekt
n13:ME10044 n13:1M0538
n4:rokUplatneniVysledku
n11:2011
n4:svazekPeriodika
11
n4:tvurceVysledku
Kovářová, Hana Motlík, Jan Skalníková, Helena Gadher, S. J.
n4:wos
000287941800013
n4:zamer
n7:AV0Z50450515
s:issn
1615-9853
s:numberOfPages
18