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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F10%3A00391644%21RIV13-MZ0-67985904
rdf:type
skos:Concept n16:Vysledek
dcterms:description
The primary aim of this study was to search for specific differences in protein composition of human follicular fluid (HFF) and plasma in order to identify proteins that accumulate or are absent in HFF. Depletion of abundant proteins combined with multidimensional protein fractionation allowed the study of middle- and lower-abundance proteins. Paired comparison study examining HFF with plasma/serum from women undergoing successful IVF revealed important differences in the protein composition which may improve our knowledge of the follicular microenvironment and its biological role. This study showed involvement of innate immune function of complement cascade in HFF Complement inhibition and the presence of C-terminal fragment of perlecan suggested possible links to angiogenesis which is a vital process in folliculogenesis and placental development. Differences in proteins associated with blood coagulation were also found in the follicular milieu. The primary aim of this study was to search for specific differences in protein composition of human follicular fluid (HFF) and plasma in order to identify proteins that accumulate or are absent in HFF. Depletion of abundant proteins combined with multidimensional protein fractionation allowed the study of middle- and lower-abundance proteins. Paired comparison study examining HFF with plasma/serum from women undergoing successful IVF revealed important differences in the protein composition which may improve our knowledge of the follicular microenvironment and its biological role. This study showed involvement of innate immune function of complement cascade in HFF Complement inhibition and the presence of C-terminal fragment of perlecan suggested possible links to angiogenesis which is a vital process in folliculogenesis and placental development. Differences in proteins associated with blood coagulation were also found in the follicular milieu.
dcterms:title
Proteome Mining of Human Follicular Fluid Reveals a Crucial Role of Complement Cascade and Key Biological Pathways in Women Undergoing in Vitro Fertilization Proteome Mining of Human Follicular Fluid Reveals a Crucial Role of Complement Cascade and Key Biological Pathways in Women Undergoing in Vitro Fertilization
skos:prefLabel
Proteome Mining of Human Follicular Fluid Reveals a Crucial Role of Complement Cascade and Key Biological Pathways in Women Undergoing in Vitro Fertilization Proteome Mining of Human Follicular Fluid Reveals a Crucial Role of Complement Cascade and Key Biological Pathways in Women Undergoing in Vitro Fertilization
skos:notation
RIV/67985904:_____/10:00391644!RIV13-MZ0-67985904
n4:aktivita
n15:N n15:P n15:Z
n4:aktivity
N, P(1QS500450568), P(NS9781), Z(AV0Z50200510), Z(AV0Z50450515)
n4:cisloPeriodika
3
n4:dodaniDat
n5:2013
n4:domaciTvurceVysledku
n19:1147633 n19:4640225 n19:8749779 n19:2495856
n4:druhVysledku
n13:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
283073
n4:idVysledku
RIV/67985904:_____/10:00391644
n4:jazykVysledku
n9:eng
n4:klicovaSlova
Human follicular fluid; plasma; assisted reproduction
n4:klicoveSlovo
n12:assisted%20reproduction n12:plasma n12:Human%20follicular%20fluid
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[D3182F3752C4]
n4:nazevZdroje
Journal of Proteome Research
n4:obor
n6:FK
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
8
n4:projekt
n10:NS9781 n10:1QS500450568
n4:rokUplatneniVysledku
n5:2010
n4:svazekPeriodika
9
n4:tvurceVysledku
Gadher, S. J. Rezábek, K. Halada, Petr Lišková, Lucie Martinková, Jiřina Kovářová, Hana Moos, J. Jarkovská, Karla
n4:wos
000275088100012
n4:zamer
n14:AV0Z50450515 n14:AV0Z50200510
s:issn
1535-3893
s:numberOfPages
13
n7:doi
10.1021/pr900802u