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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F10%3A00359477%21RIV12-AV0-67985904
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Mammalian oocytes are arrested at prophase I until puberty when luteinizing hormone (LH) induces resumption of meiosis of follicle-enclosed oocytes. Resumption of meiosis is tightly coupled with regulating cyclin-dependent kinase 1 (CDK1) activity. Prophase I arrest depends on inhibitory phosphorylation of CDK1 and anaphase-promoting complex-(APC-CDH1)-mediated regulation of cyclin B levels. Prophase I arrest is maintained by endogenously produced cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA) that in turn phosphorylates (and activates) the nuclear kinase WEE2. In addition, PKA-mediated phosphorylation of the phosphatase CDC25B results in its cytoplasmic retention. The combined effect maintains low levels of CDK1 activity that are not sufficient to initiate resumption of meiosis. Mammalian oocytes are arrested at prophase I until puberty when luteinizing hormone (LH) induces resumption of meiosis of follicle-enclosed oocytes. Resumption of meiosis is tightly coupled with regulating cyclin-dependent kinase 1 (CDK1) activity. Prophase I arrest depends on inhibitory phosphorylation of CDK1 and anaphase-promoting complex-(APC-CDH1)-mediated regulation of cyclin B levels. Prophase I arrest is maintained by endogenously produced cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA) that in turn phosphorylates (and activates) the nuclear kinase WEE2. In addition, PKA-mediated phosphorylation of the phosphatase CDC25B results in its cytoplasmic retention. The combined effect maintains low levels of CDK1 activity that are not sufficient to initiate resumption of meiosis.
dcterms:title
Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells
skos:prefLabel
Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells
skos:notation
RIV/67985904:_____/10:00359477!RIV12-AV0-67985904
n3:aktivita
n18:P n18:Z
n3:aktivity
P(GC301/09/J036), P(ME08030), Z(AV0Z50450515)
n3:cisloPeriodika
9
n3:dodaniDat
n14:2012
n3:domaciTvurceVysledku
n12:8523487 n12:5434505
n3:druhVysledku
n17:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
282949
n3:idVysledku
RIV/67985904:_____/10:00359477
n3:jazykVysledku
n16:eng
n3:klicovaSlova
resumption of meiosis; prophase I arrest; oocyte
n3:klicoveSlovo
n8:prophase%20I%20arrest n8:oocyte n8:resumption%20of%20meiosis
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[2AACC0742D92]
n3:nazevZdroje
Molecular Human Reproduction
n3:obor
n15:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:projekt
n10:ME08030 n10:GC301%2F09%2FJ036
n3:rokUplatneniVysledku
n14:2010
n3:svazekPeriodika
16
n3:tvurceVysledku
Šolc, Petr Schultz, R. M. Motlík, Jan
n3:wos
000281535400006
n3:zamer
n19:AV0Z50450515
s:issn
1360-9947
s:numberOfPages
11
n13:doi
10.1093/molehr/gaq034