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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F10%3A00345865%21RIV11-MSM-67985904
rdf:type
skos:Concept n5:Vysledek
dcterms:description
Preparation of soft poly(amino acid) hydrogels containing biomimetic cell-adhesive peptides was investigated. Covalently crosslinked gels were formed by radical co-polymerization of methacryloylated macromonomer poly[N5-(2-hydroxyethyl)-L-glutamine-stat-L-alanine-stat-methacryloyllysine] with 2-hydroxyethyl methacrylate (HEMA) as minor co-monomer. Hydrogels carrying biomimetic peptides were prepared by using methacryloylated peptides, such as methacryloyl-GGGRGDSG-OH and methacryloyl-GGGYIGSR-OH, as additional monomers in the polymerization mixture. While unmodified hydrogels showed very low cell adhesion, due to their highly hydrophilic nature, the incorporation of adhesive peptides significantly improved the adhesion and viability of seeded cells. Preparation of soft poly(amino acid) hydrogels containing biomimetic cell-adhesive peptides was investigated. Covalently crosslinked gels were formed by radical co-polymerization of methacryloylated macromonomer poly[N5-(2-hydroxyethyl)-L-glutamine-stat-L-alanine-stat-methacryloyllysine] with 2-hydroxyethyl methacrylate (HEMA) as minor co-monomer. Hydrogels carrying biomimetic peptides were prepared by using methacryloylated peptides, such as methacryloyl-GGGRGDSG-OH and methacryloyl-GGGYIGSR-OH, as additional monomers in the polymerization mixture. While unmodified hydrogels showed very low cell adhesion, due to their highly hydrophilic nature, the incorporation of adhesive peptides significantly improved the adhesion and viability of seeded cells.
dcterms:title
Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering
skos:prefLabel
Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering
skos:notation
RIV/67985904:_____/10:00345865!RIV11-MSM-67985904
n3:aktivita
n12:P n12:Z
n3:aktivity
P(1M0538), P(KJB400500801), Z(AV0Z40500505), Z(AV0Z50450515)
n3:cisloPeriodika
6
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n7:5434505 n7:8905029 n7:4536096
n3:druhVysledku
n9:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
291572
n3:idVysledku
RIV/67985904:_____/10:00345865
n3:jazykVysledku
n15:eng
n3:klicovaSlova
polyamino acid; hydrogel; porosity
n3:klicoveSlovo
n14:porosity n14:polyamino%20acid n14:hydrogel
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[36E77F2DA2AD]
n3:nazevZdroje
Journal of Tissue Engineering and Regenerative Medicine
n3:obor
n16:CD
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
6
n3:projekt
n11:KJB400500801 n11:1M0538
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
4
n3:tvurceVysledku
Motlík, Jan Studenovská, Hana Vodička, Petr Proks, Vladimír Hlučilová, Jana Rypáček, František
n3:wos
000281152400005
n3:zamer
n6:AV0Z40500505 n6:AV0Z50450515
s:issn
1932-6254
s:numberOfPages
10