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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F09%3A00337303%21RIV10-AV0-67985904
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Regulation of gene expression at the translational level is particularly essential during developmental periods, when transcription is impaired. According to the closed-loop model of translational initiation, we have analyzed components of the 5'-mRNA cap-binding complex eIF4F (eIF4E, eIF4G, eIF4A), the eIF4E repressor 4E-BP1, and 3'-mRNA poly-(A) tail-associated proteins (PABP1 and 3, PAIP1 and 2, CPEB1, Maskin) during in vitro maturation of bovine oocytes and early embryonic development up to the 16-cell stage. Furthermore, we have elucidated the activity of distinct kinases which are potentially involved in their phosphorylation. Major phosphorylation of specific target sequences of PKA, PKB, PKC, CDKs, ATM/ATR, and MAPK were observed in M II stage oocytes. Furthermore, main changes in the abundance and/or phosphorylation of distinct mRNA-binding factors occur at the transition from M II stage oocytes to 2-cell embryos. Regulation of gene expression at the translational level is particularly essential during developmental periods, when transcription is impaired. According to the closed-loop model of translational initiation, we have analyzed components of the 5'-mRNA cap-binding complex eIF4F (eIF4E, eIF4G, eIF4A), the eIF4E repressor 4E-BP1, and 3'-mRNA poly-(A) tail-associated proteins (PABP1 and 3, PAIP1 and 2, CPEB1, Maskin) during in vitro maturation of bovine oocytes and early embryonic development up to the 16-cell stage. Furthermore, we have elucidated the activity of distinct kinases which are potentially involved in their phosphorylation. Major phosphorylation of specific target sequences of PKA, PKB, PKC, CDKs, ATM/ATR, and MAPK were observed in M II stage oocytes. Furthermore, main changes in the abundance and/or phosphorylation of distinct mRNA-binding factors occur at the transition from M II stage oocytes to 2-cell embryos.
dcterms:title
Analysis of mRNA Associated factors During Bovine Oocyte Maturation and Early Embryonic Development Analysis of mRNA Associated factors During Bovine Oocyte Maturation and Early Embryonic Development
skos:prefLabel
Analysis of mRNA Associated factors During Bovine Oocyte Maturation and Early Embryonic Development Analysis of mRNA Associated factors During Bovine Oocyte Maturation and Early Embryonic Development
skos:notation
RIV/67985904:_____/09:00337303!RIV10-AV0-67985904
n3:aktivita
n6:P n6:Z
n3:aktivity
P(GA524/07/1087), Z(AV0Z50450515)
n3:cisloPeriodika
12
n3:dodaniDat
n11:2010
n3:domaciTvurceVysledku
n15:1114921
n3:druhVysledku
n18:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
302900
n3:idVysledku
RIV/67985904:_____/09:00337303
n3:jazykVysledku
n10:eng
n3:klicovaSlova
In Vitro maturation; Poly(A) binding protein; Initiation-factor 4E
n3:klicoveSlovo
n9:Poly%28A%29%20binding%20protein n9:In%20Vitro%20maturation n9:Initiation-factor%204E
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[A1F0E0323CAE]
n3:nazevZdroje
Molecular Reproduction and Development
n3:obor
n7:ED
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n12:GA524%2F07%2F1087
n3:rokUplatneniVysledku
n11:2009
n3:svazekPeriodika
76
n3:tvurceVysledku
Tomek, W. Bhojawni, M. Kanitz, W. Smiljakovic, T. Kubelka, Michal Siemer, C. Leiding, C.
n3:wos
000271361500012
n3:zamer
n13:AV0Z50450515
s:issn
1040-452X
s:numberOfPages
12