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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F09%3A00330776%21RIV10-MSM-67985904
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Transplantation of stem cells represents a unique approach to treat spinal trauma. To follow in vivo traumatic changes, the signalling proteins were studied in the rat spinal cord transsection. 80th motoneurons and sensory neurons were subjected to analysis. Computer modeling of protein changes indicates that downregulated proteins belong to oxidative stress response as well as cellular fate and organisation. Increase of proteins involved in genome maintenance was observed in ventral horns. Only marginal changes were found in the dorsal root ganglia. To characterise mechanisms governing differentiation we combined the porcine neural stem cells in vitro differentiation and complementary proteomic analyses. The stem cells exhibited high levels of GRK2 and several members of FAS pathway. Typical for differentiated neural cells were enhanced integrin, PDGF and MAP kinase signalling and heme-oxygenase 2. Characterisation of changes related to cell differentiation helps to define suitab Transplantation of stem cells represents a unique approach to treat spinal trauma. To follow in vivo traumatic changes, the signalling proteins were studied in the rat spinal cord transsection. 80th motoneurons and sensory neurons were subjected to analysis. Computer modeling of protein changes indicates that downregulated proteins belong to oxidative stress response as well as cellular fate and organisation. Increase of proteins involved in genome maintenance was observed in ventral horns. Only marginal changes were found in the dorsal root ganglia. To characterise mechanisms governing differentiation we combined the porcine neural stem cells in vitro differentiation and complementary proteomic analyses. The stem cells exhibited high levels of GRK2 and several members of FAS pathway. Typical for differentiated neural cells were enhanced integrin, PDGF and MAP kinase signalling and heme-oxygenase 2. Characterisation of changes related to cell differentiation helps to define suitab
dcterms:title
Targed neural stem cell differentiation and related cell based therapy in spinal cord injury Targed neural stem cell differentiation and related cell based therapy in spinal cord injury
skos:prefLabel
Targed neural stem cell differentiation and related cell based therapy in spinal cord injury Targed neural stem cell differentiation and related cell based therapy in spinal cord injury
skos:notation
RIV/67985904:_____/09:00330776!RIV10-MSM-67985904
n3:aktivita
n6:Z n6:P
n3:aktivity
P(1M0538), Z(AV0Z50200510), Z(AV0Z50450515)
n3:dodaniDat
n20:2010
n3:domaciTvurceVysledku
n7:8905029 n7:6541186 n7:1147633 n7:5434505
n3:druhVysledku
n14:D
n3:duvernostUdaju
n21:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
345373
n3:idVysledku
RIV/67985904:_____/09:00330776
n3:jazykVysledku
n13:eng
n3:klicovaSlova
stem cells; cell therapy; spinal cord injury
n3:klicoveSlovo
n8:spinal%20cord%20injury n8:cell%20therapy n8:stem%20cells
n3:kontrolniKodProRIV
[E54D15229606]
n3:mistoKonaniAkce
Budapešť
n3:mistoVydani
Budapest
n3:nazevZdroje
3rd Central and Eastern Proteomics Conference, 2009
n3:obor
n18:FH
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
7
n3:projekt
n10:1M0538
n3:rokUplatneniVysledku
n20:2009
n3:tvurceVysledku
Vodička, Petr Gadher, S. J. Kovářová, Hana Skalníková, Helena Maršala, M. Motlík, Jan Halada, Petr
n3:typAkce
n11:EUR
n3:zahajeniAkce
2009-10-06+02:00
n3:zamer
n4:AV0Z50450515 n4:AV0Z50200510
s:numberOfPages
1
n17:hasPublisher
Hungarian proteomic society
n15:isbn
978-963-9319-99-8