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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F09%3A00328392%21RIV10-MSM-67985904
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Ependymal cells (EC) in the spinal cord central canal (CC) are believed to be responsible for the postnatal neurogenesis following pathological or stimulatory conditions. In this study, we have analyzed the proliferation of the CC ependymal progenitors in adult rats processed to compression SCI or enhanced physical activity. To label dividing cells, a single daily injection of Bromo-deoxyuridine (BrdU) was administered over a 14-day-survival period. Systematic quantification of BrdU-positive ependymal progenitors was performed by using stereological principles of systematic, random sampling, and optical Dissector software. The number of proliferating BrdUlabeled EC increased gradually with the time of survival after both paradigms, spinal cord injury, or increased physical activity. In the spinal cord injury group, we have found 4.9-fold (4 days), 7.1-fold (7 days), 4.9-fold (10 days), and 5.6-fold (14 days) increase of proliferating EC in the rostro-caudal regions, 4 mm away from the epicenter. In... Ependymal cells (EC) in the spinal cord central canal (CC) are believed to be responsible for the postnatal neurogenesis following pathological or stimulatory conditions. In this study, we have analyzed the proliferation of the CC ependymal progenitors in adult rats processed to compression SCI or enhanced physical activity. To label dividing cells, a single daily injection of Bromo-deoxyuridine (BrdU) was administered over a 14-day-survival period. Systematic quantification of BrdU-positive ependymal progenitors was performed by using stereological principles of systematic, random sampling, and optical Dissector software. The number of proliferating BrdUlabeled EC increased gradually with the time of survival after both paradigms, spinal cord injury, or increased physical activity. In the spinal cord injury group, we have found 4.9-fold (4 days), 7.1-fold (7 days), 4.9-fold (10 days), and 5.6-fold (14 days) increase of proliferating EC in the rostro-caudal regions, 4 mm away from the epicenter. In...
dcterms:title
Response of Ependymal Progenitors to Spinal Cord Injury or Enhanced Physical Activity in Adult Rat Response of Ependymal Progenitors to Spinal Cord Injury or Enhanced Physical Activity in Adult Rat
skos:prefLabel
Response of Ependymal Progenitors to Spinal Cord Injury or Enhanced Physical Activity in Adult Rat Response of Ependymal Progenitors to Spinal Cord Injury or Enhanced Physical Activity in Adult Rat
skos:notation
RIV/67985904:_____/09:00328392!RIV10-MSM-67985904
n3:aktivita
n10:Z n10:P
n3:aktivity
P(MEB0808108), Z(AV0Z50450515)
n3:cisloPeriodika
6-7
n3:dodaniDat
n18:2010
n3:domaciTvurceVysledku
n7:5434505 n7:4536096
n3:druhVysledku
n4:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
339172
n3:idVysledku
RIV/67985904:_____/09:00328392
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Spinal cord injury; Neural stem cells; BrdU
n3:klicoveSlovo
n13:BrdU n13:Neural%20stem%20cells n13:Spinal%20cord%20injury
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[3E56EAA9200E]
n3:nazevZdroje
Cellular and Molecular Neurobiology
n3:obor
n16:FH
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
12
n3:projekt
n15:MEB0808108
n3:rokUplatneniVysledku
n18:2009
n3:svazekPeriodika
29
n3:tvurceVysledku
Slovinská, L. Motlík, Jan Nagyová, M. Tomori, Z. Čížková, D. Mechirová, E. Novotná, I. Radoňák, J. Čížek, M. Hlučilová, Jana Vanický, I. Sulla, I.
n3:wos
000268482300027
n3:zamer
n9:AV0Z50450515
s:issn
0272-4340
s:numberOfPages
15