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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F08%3A00316957%21RIV09-AV0-67985904
rdf:type
skos:Concept n18:Vysledek
dcterms:description
The spatiotemporal distribution of the endothelin-converting enzyme (ECE) protein in the embryonic chick heart and the association of this polypeptide with the developing cardiac conduction system is described here for the first time. Further, we show how cardiac hemodynamic load directly affects ECE level and distribution. Endothelin (ET) is a cytokine involved in the inductive recruitment of Purkinje fibers. ET is produced by proteolytic cleavage of Big-ET by ECE. We generated an antibody against chick ECE recognizing a single band at approximately 70 kD to correlate the cardiac expression of this protein with that reported previously for its mRNA. ECE protein expression was more widespread compared to its mRNA, being present in endothelial cells, mesenchymal cells, and myocytes, and particularly enriched in the trabeculae and nascent ventricular conduction system. The myocardial expression was significantly modified under experimentally altered hemodynamic loading. In vivo, ET receptor blockade ... Exprese endothelin-konvertujícího enzymu během vývoje podporuje spolu s jejími změnami podmíněnými hemodynamikou a následky farmakologické blokády hypotézu, že endotelinová signalizace hraje významnou úlohu při normální specifikaci převodního systému. The spatiotemporal distribution of the endothelin-converting enzyme (ECE) protein in the embryonic chick heart and the association of this polypeptide with the developing cardiac conduction system is described here for the first time. Further, we show how cardiac hemodynamic load directly affects ECE level and distribution. Endothelin (ET) is a cytokine involved in the inductive recruitment of Purkinje fibers. ET is produced by proteolytic cleavage of Big-ET by ECE. We generated an antibody against chick ECE recognizing a single band at approximately 70 kD to correlate the cardiac expression of this protein with that reported previously for its mRNA. ECE protein expression was more widespread compared to its mRNA, being present in endothelial cells, mesenchymal cells, and myocytes, and particularly enriched in the trabeculae and nascent ventricular conduction system. The myocardial expression was significantly modified under experimentally altered hemodynamic loading. In vivo, ET receptor blockade ...
dcterms:title
Cardiac expression patterns of endothelin-converting enzyme (ECE): Implications for conduction system development Exprese endothelin-konvertujícího enzymu v srdci: implikace pro vývoj převodního systému Cardiac expression patterns of endothelin-converting enzyme (ECE): Implications for conduction system development
skos:prefLabel
Cardiac expression patterns of endothelin-converting enzyme (ECE): Implications for conduction system development Cardiac expression patterns of endothelin-converting enzyme (ECE): Implications for conduction system development Exprese endothelin-konvertujícího enzymu v srdci: implikace pro vývoj převodního systému
skos:notation
RIV/67985904:_____/08:00316957!RIV09-AV0-67985904
n3:aktivita
n10:P n10:Z
n3:aktivity
P(GA304/08/0615), Z(AV0Z50450515), Z(MSM0021620806)
n3:cisloPeriodika
-
n3:dodaniDat
n8:2009
n3:domaciTvurceVysledku
n11:5754623
n3:druhVysledku
n9:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
358841
n3:idVysledku
RIV/67985904:_____/08:00316957
n3:jazykVysledku
n7:eng
n3:klicovaSlova
chick embryo; heart development; immunohistochemistry
n3:klicoveSlovo
n6:heart%20development n6:immunohistochemistry n6:chick%20embryo
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[268904284F0F]
n3:nazevZdroje
Developmental Dynamics
n3:obor
n13:FA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n17:GA304%2F08%2F0615
n3:rokUplatneniVysledku
n8:2008
n3:svazekPeriodika
237
n3:tvurceVysledku
Harris, B. S. Kurková, D. Jourdan, J. Zhang, N. Sedmera, David Grant, E. Gourdie, R. G.
n3:wos
000256652300022
n3:zamer
n4:MSM0021620806 n4:AV0Z50450515
s:issn
1058-8388
s:numberOfPages
8