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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F08%3A00312613%21RIV09-AV0-67985904
rdf:type
n10:Vysledek skos:Concept
dcterms:description
In this study we document that both the translation initiation factor eIF4E and its regulator 4E-BP1 become dephosphorylated in the early stage porcine zygotes already 8 hr post-activation.Similarly, the activities of ERK1/2 MAP and Mnk1 kinases, which are both involved in eIF4E phosphorylation, gradually decrease during this period with the timing similar to that of eIF4E dephosphorylation. The formation of an active eIF4F complex is also diminished after 9-15 hr post-activation, although substantial amounts of this complex have been detected also 24 hr post-activation (2-cell stage). The overall protein synthesis in the parthenotes decreases gradually from 12 hr post-activation reaching a minimum after 48 hr (4-cell stage). Although the translation is gradually decreasing during early preimplantation development, the eIF4F complex, which is temporarily formed, might be a premise for the translation of a small subset of mRNAs at this period of development. In this study we document that both the translation initiation factor eIF4E and its regulator 4E-BP1 become dephosphorylated in the early stage porcine zygotes already 8 hr post-activation.Similarly, the activities of ERK1/2 MAP and Mnk1 kinases, which are both involved in eIF4E phosphorylation, gradually decrease during this period with the timing similar to that of eIF4E dephosphorylation. The formation of an active eIF4F complex is also diminished after 9-15 hr post-activation, although substantial amounts of this complex have been detected also 24 hr post-activation (2-cell stage). The overall protein synthesis in the parthenotes decreases gradually from 12 hr post-activation reaching a minimum after 48 hr (4-cell stage). Although the translation is gradually decreasing during early preimplantation development, the eIF4F complex, which is temporarily formed, might be a premise for the translation of a small subset of mRNAs at this period of development. V této studii dokumentujeme, že translační iniciační faktor eIF4E a jeho regulátor 4E-BP1 jsou defosforylovány v časných prasečích zygotách již za 8 hod po aktivaci. Současně se snižuje aktivita ERK1/2 MAP and Mnk1 kináz. Tvorba aktivního eIF4F komplexu je rovněž snížena 9-15 hod po aktivaci ale za 24 hod je opět detekována jeho podstatná hladina. Proteosyntéza průběžně klesá do 48 hod.. Přestože je translace v preimplantačním stadiu průběžně snižována, může mít přechodná tvorba eIF4F komplexu vliv na translaci malého subsetu mRNA v této vývojové periodě.
dcterms:title
Regulation of cap-dependent translation initiation in the early stage porcine parthenotes Regulace na čepičce závislé translační iniciace závislé v časném prasečím partenotu Regulation of cap-dependent translation initiation in the early stage porcine parthenotes
skos:prefLabel
Regulace na čepičce závislé translační iniciace závislé v časném prasečím partenotu Regulation of cap-dependent translation initiation in the early stage porcine parthenotes Regulation of cap-dependent translation initiation in the early stage porcine parthenotes
skos:notation
RIV/67985904:_____/08:00312613!RIV09-AV0-67985904
n4:aktivita
n5:P n5:Z
n4:aktivity
P(GA524/04/0104), P(GA524/07/1087), Z(AV0Z50450515)
n4:cisloPeriodika
12
n4:dodaniDat
n13:2009
n4:domaciTvurceVysledku
n8:2495856 n8:6275532 n8:1147633 n8:3064468 n8:1114921
n4:druhVysledku
n6:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
392056
n4:idVysledku
RIV/67985904:_____/08:00312613
n4:jazykVysledku
n17:eng
n4:klicovaSlova
meiosis; translation initiation; porcine parthenotes
n4:klicoveSlovo
n15:translation%20initiation n15:porcine%20parthenotes n15:meiosis
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[785C3B76EF9D]
n4:nazevZdroje
Molecular Reproduction and Development
n4:obor
n18:EB
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
7
n4:projekt
n14:GA524%2F07%2F1087 n14:GA524%2F04%2F0104
n4:rokUplatneniVysledku
n13:2008
n4:svazekPeriodika
75
n4:tvurceVysledku
Karabínová, Pavla Šušor, Andrej Kovářová, Hana Kubelka, Michal Jelínková, Lucie Torner, H. Tomek, W.
n4:wos
000260873200004
n4:zamer
n16:AV0Z50450515
s:issn
1040-452X
s:numberOfPages
10