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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F06%3A00045049%21RIV07-AV0-67985904
rdf:type
n11:Vysledek skos:Concept
dcterms:description
The retinal fascin 2 gene (FSCN2) underwent a molecular analysis, a search for polymorphisms and an evaluation as a candidate gene for retinopathies in dogs. Specific fragments of the gene encompassing partial exon 1 and intron 1, and exons 2-5 with respective introns were sequenced and these data were deposited in the GenBank database. Three distinct polymorphic sites detectable with PCR-RFLP were found - AM050719: g.237G > A, AM050719: g.525A > G, and AM050720: g.1071A > G. No positive associations between these polymorphisms and the PRA-clinical status were observed in the investigated population consisting of Poodles, American Cocker Spaniels, and English Cocker Spaniels. In spite of that, the FSCN2 gene remains an excellent candidate gene for retinopathies in dogs and the results can contribute to further research in this field. The retinal fascin 2 gene (FSCN2) underwent a molecular analysis, a search for polymorphisms and an evaluation as a candidate gene for retinopathies in dogs. Specific fragments of the gene encompassing partial exon 1 and intron 1, and exons 2-5 with respective introns were sequenced and these data were deposited in the GenBank database. Three distinct polymorphic sites detectable with PCR-RFLP were found - AM050719: g.237G > A, AM050719: g.525A > G, and AM050720: g.1071A > G. No positive associations between these polymorphisms and the PRA-clinical status were observed in the investigated population consisting of Poodles, American Cocker Spaniels, and English Cocker Spaniels. In spite of that, the FSCN2 gene remains an excellent candidate gene for retinopathies in dogs and the results can contribute to further research in this field. Gen retinálního fascinu 2 (FSCN2) byl podroben molekulární analýze, vyhledávání polymorfismu a hodnocení jako kandidátního genu pro retinopatie u psů. Oblasti genu zahrnující částečný exon 1 a intron 1 a exony 2-5 s příslušnými introny byly sekvenovány a sekvence byly uloženy v databázi GenBank. V genu byly identifikovány tři PCR-RFLP polymorfismy - AM050719:g.237G>A, AM050719:g.525A>G, a AM050720:g.1071A>G. Ačkoli nebyly objeveny žádné pozitivní asociace mezi uvedenými polymorfismy a progresivní retinální atrofií ve zkoumané populaci plemen pudl, americký kokršpaněl a anglický kokršpaněl, zůstává gen FSCN2 zajímavým kandidátním genem pro dědičná onemocnění sítnice u psů.
dcterms:title
Gen retinálního fascinu 2 (FSCN2) – částečná strukturní analýza a detekce polymorfismu u psů postižených progresivní retinální atrofií (PRA) The retinal fascin gene 2 (FSCN2) - partial structural analysis and polymorphisms detection in dogs with progressive retinal atrophy (PRA) The retinal fascin gene 2 (FSCN2) - partial structural analysis and polymorphisms detection in dogs with progressive retinal atrophy (PRA)
skos:prefLabel
Gen retinálního fascinu 2 (FSCN2) – částečná strukturní analýza a detekce polymorfismu u psů postižených progresivní retinální atrofií (PRA) The retinal fascin gene 2 (FSCN2) - partial structural analysis and polymorphisms detection in dogs with progressive retinal atrophy (PRA) The retinal fascin gene 2 (FSCN2) - partial structural analysis and polymorphisms detection in dogs with progressive retinal atrophy (PRA)
skos:notation
RIV/67985904:_____/06:00045049!RIV07-AV0-67985904
n3:strany
361;364
n3:aktivita
n4:Z n4:P
n3:aktivity
P(1QS500450578), Z(AV0Z50450515)
n3:cisloPeriodika
4
n3:dodaniDat
n8:2007
n3:domaciTvurceVysledku
n7:2529157 n7:9635343
n3:druhVysledku
n10:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
497456
n3:idVysledku
RIV/67985904:_____/06:00045049
n3:jazykVysledku
n14:eng
n3:klicovaSlova
canis familiaris; FSCN2 gene; PCR-RFLP
n3:klicoveSlovo
n9:canis%20familiaris n9:PCR-RFLP n9:FSCN2%20gene
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[C7E4F4B5ADD9]
n3:nazevZdroje
Journal of Applied Genetics
n3:obor
n12:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:projekt
n18:1QS500450578
n3:rokUplatneniVysledku
n8:2006
n3:svazekPeriodika
47
n3:tvurceVysledku
Knoll, Aleš Horák, Pavel Dvořák, J.
n3:zamer
n16:AV0Z50450515
s:issn
1234-1983
s:numberOfPages
4