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Statements

Subject Item
n2:RIV%2F67985904%3A_____%2F03%3A21033079%21RIV%2F2004%2FGA0%2FA21004%2FN
rdf:type
n13:Vysledek skos:Concept
dcterms:description
The presence of truncated form of cyclin A2 has been reported in various murine cell lines and tissues. In this paper it was shown that while undifferentiated proliferating mouse embryonic stem cells express low levels of this truncated cyclin A2, cells that are induced to differentiate remarkably increase its synthesis. Importantly, the expression pattern of truncated cyclin A2 was the same in p27 -/- ES cells as in the wild-type ES cells. Thus, it suggests that p27 is not necessary for the proteolytic cleavage of cyclin A2 and that this post-translational modification correlates with differentiation. The presence of truncated form of cyclin A2 has been reported in various murine cell lines and tissues. In this paper it was shown that while undifferentiated proliferating mouse embryonic stem cells express low levels of this truncated cyclin A2, cells that are induced to differentiate remarkably increase its synthesis. Importantly, the expression pattern of truncated cyclin A2 was the same in p27 -/- ES cells as in the wild-type ES cells. Thus, it suggests that p27 is not necessary for the proteolytic cleavage of cyclin A2 and that this post-translational modification correlates with differentiation.
dcterms:title
The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells. The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells.
skos:prefLabel
The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells. The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells.
skos:notation
RIV/67985904:_____/03:21033079!RIV/2004/GA0/A21004/N
n3:strany
825;830
n3:aktivita
n15:P n15:Z
n3:aktivity
P(GA523/00/0780), P(LN00A065), Z(AV0Z5039906), Z(AV0Z5045916)
n3:cisloPeriodika
N/A
n3:dodaniDat
n9:2004
n3:domaciTvurceVysledku
n12:5434505 n12:2188554 n12:1114921
n3:druhVysledku
n10:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
598808
n3:idVysledku
RIV/67985904:_____/03:21033079
n3:jazykVysledku
n18:eng
n3:klicovaSlova
mouse embryonic stem cell
n3:klicoveSlovo
n4:mouse%20embryonic%20stem%20cell
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[30118418C2CD]
n3:nazevZdroje
Biochemical and Biophysical Research Communications
n3:obor
n14:ED
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
8
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n11:LN00A065 n11:GA523%2F00%2F0780
n3:rokUplatneniVysledku
n9:2003
n3:svazekPeriodika
302
n3:tvurceVysledku
Dvořák, Petr Anger, Martin Hampl, Aleš Kubelka, Michal Jirmanová, L. Carrington, M. Motlík, Jan Bryja, Vítězslav
n3:zamer
n8:AV0Z5045916 n8:AV0Z5039906
s:issn
0006-291X
s:numberOfPages
6