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Statements

Subject Item
n2:RIV%2F67985882%3A_____%2F14%3A00441142%21RIV15-GA0-67985882
rdf:type
skos:Concept n18:Vysledek
dcterms:description
New composite layer architecture of 3D hydrogel polymer network that is loaded with molecularly imprinted polymer nanoparticles (nanoMIP) is reported for direct optical detection of low-molecular-weight compounds. This composite layer is attached to the metallic surface of a surface plasmon resonance (SPR) sensor in order to simultaneously serve as an optical waveguide and large capacity binding-matrix for imprinted target analyte. Optical waveguide spectroscopy (OWS) is used as a label-free readout method allowing direct measurement of refractive index changes that are associated with molecular binding events inside the matrix. This approach is implemented by using a photocrosslinkable poly(N-isopropylacrylamide)-based hydrogel and poly[(ethylene glycol dimethylacrylate)-(methacrylic acid)] nanoparticles that are imprinted with L-Boc-phenylalanine-anilide (L-BFA, molecular weight 353 g mol(-1)). Titration experiments with the specific target and other structurally similar reference compounds show good specifi city and limit of detection for target L-BFA as low as 2 x 10(-6) M New composite layer architecture of 3D hydrogel polymer network that is loaded with molecularly imprinted polymer nanoparticles (nanoMIP) is reported for direct optical detection of low-molecular-weight compounds. This composite layer is attached to the metallic surface of a surface plasmon resonance (SPR) sensor in order to simultaneously serve as an optical waveguide and large capacity binding-matrix for imprinted target analyte. Optical waveguide spectroscopy (OWS) is used as a label-free readout method allowing direct measurement of refractive index changes that are associated with molecular binding events inside the matrix. This approach is implemented by using a photocrosslinkable poly(N-isopropylacrylamide)-based hydrogel and poly[(ethylene glycol dimethylacrylate)-(methacrylic acid)] nanoparticles that are imprinted with L-Boc-phenylalanine-anilide (L-BFA, molecular weight 353 g mol(-1)). Titration experiments with the specific target and other structurally similar reference compounds show good specifi city and limit of detection for target L-BFA as low as 2 x 10(-6) M
dcterms:title
Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low-Molecular-Weight Analytes Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low-Molecular-Weight Analytes
skos:prefLabel
Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low-Molecular-Weight Analytes Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low-Molecular-Weight Analytes
skos:notation
RIV/67985882:_____/14:00441142!RIV15-GA0-67985882
n3:aktivita
n6:I n6:P
n3:aktivity
I, P(GBP205/12/G118)
n3:cisloPeriodika
23
n3:dodaniDat
n5:2015
n3:domaciTvurceVysledku
n10:9632689 n10:6624634 n10:5874599
n3:druhVysledku
n13:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
30314
n3:idVysledku
RIV/67985882:_____/14:00441142
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Label-free biosensors; Molecularly imprinted polymers; Hydrogels
n3:klicoveSlovo
n8:Hydrogels n8:Molecularly%20imprinted%20polymers n8:Label-free%20biosensors
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[6E3CF16D6F03]
n3:nazevZdroje
Macromolecular Chemistry and Physics
n3:obor
n11:JA
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
10
n3:projekt
n9:GBP205%2F12%2FG118
n3:rokUplatneniVysledku
n5:2014
n3:svazekPeriodika
215
n3:tvurceVysledku
Tovar, G. Bach, M. Vala, Milan Jonas, U. Homola, Jiří Knoll, W. Petri, C. Dostálek, J. Sharma, N. Mrkvová, Kateřina
n3:wos
000345966900002
s:issn
1022-1352
s:numberOfPages
10
n15:doi
10.1002/macp.201400260