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Statements

Subject Item
n2:RIV%2F67985882%3A_____%2F12%3A00374555%21RIV13-AV0-67985882
rdf:type
n5:Vysledek skos:Concept
dcterms:description
The surface plasmon resonance (SPR) biosensor system with dispersionless microfluidics for the direct and label-free detection of a soluble vascular endothelial growth factor receptor (sVEGFR-1) is described. The detection approach takes advantage of an affinity interaction between sVEGFR-1 and its ligand, vascular endothelial growth factor (VEGF-A), which is covalently immobilized on the surface of the SPR sensor. The ability of the immobilized VEGF-A to specifically bind the sVEGFR-1 receptor is demonstrated in a buffer. The detection of sVEGFR-1 in 2% human blood plasma is carried out by using the sequential injection approach. The detection limit of 25 ng/mL is achieved. In addition, we demonstrate that the functional surface of the sensor can be regenerated for repeated use. The surface plasmon resonance (SPR) biosensor system with dispersionless microfluidics for the direct and label-free detection of a soluble vascular endothelial growth factor receptor (sVEGFR-1) is described. The detection approach takes advantage of an affinity interaction between sVEGFR-1 and its ligand, vascular endothelial growth factor (VEGF-A), which is covalently immobilized on the surface of the SPR sensor. The ability of the immobilized VEGF-A to specifically bind the sVEGFR-1 receptor is demonstrated in a buffer. The detection of sVEGFR-1 in 2% human blood plasma is carried out by using the sequential injection approach. The detection limit of 25 ng/mL is achieved. In addition, we demonstrate that the functional surface of the sensor can be regenerated for repeated use.
dcterms:title
Surface plasmon resonance biosensor for the detection of VEGFR-1-a protein marker of myelodysplastic syndromes Surface plasmon resonance biosensor for the detection of VEGFR-1-a protein marker of myelodysplastic syndromes
skos:prefLabel
Surface plasmon resonance biosensor for the detection of VEGFR-1-a protein marker of myelodysplastic syndromes Surface plasmon resonance biosensor for the detection of VEGFR-1-a protein marker of myelodysplastic syndromes
skos:notation
RIV/67985882:_____/12:00374555!RIV13-AV0-67985882
n5:predkladatel
n16:ico%3A67985882
n3:aktivita
n14:P n14:Z
n3:aktivity
P(KAN200670701), P(NS10633), Z(AV0Z20670512), Z(MZ0UHKT2005)
n3:cisloPeriodika
1
n3:dodaniDat
n20:2013
n3:domaciTvurceVysledku
n4:9632689 n4:8391599 n4:5874599
n3:druhVysledku
n10:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
172555
n3:idVysledku
RIV/67985882:_____/12:00374555
n3:jazykVysledku
n7:eng
n3:klicovaSlova
surface plasmon resonance; myelodysplastic syndromes; vascular endothelial growth factor
n3:klicoveSlovo
n9:surface%20plasmon%20resonance n9:vascular%20endothelial%20growth%20factor n9:myelodysplastic%20syndromes
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[27DE8AC5DA9E]
n3:nazevZdroje
Analytical and Bioanalytical Chemistry
n3:obor
n15:JA
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
7
n3:projekt
n19:NS10633 n19:KAN200670701
n3:rokUplatneniVysledku
n20:2012
n3:svazekPeriodika
402
n3:tvurceVysledku
Pimková, K. Hegnerová, Kateřina Homola, Jiří Čermák, J. Dyr, J. E. Suttnar, J. Bocková, Markéta
n3:wos
000298749300041
n3:zamer
n12:AV0Z20670512 n12:MZ0UHKT2005
s:issn
1618-2642
s:numberOfPages
7
n13:doi
10.1007/s00216-011-5395-3