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Statements

Subject Item
n2:RIV%2F67985858%3A_____%2F09%3A00333208%21RIV11-AV0-67985858
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibited by paraoxon. Their reactivation activity was compared with standard reactivators—pralidoxime, obidoxime and HI-6—which are clinically used at present. As it resulted, none of the prepared compounds surpassed obidoxime. In case of BuChE reactivation, two compounds (K053 and K068) achieved similar results as obidoxime. Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibited by paraoxon. Their reactivation activity was compared with standard reactivators—pralidoxime, obidoxime and HI-6—which are clinically used at present. As it resulted, none of the prepared compounds surpassed obidoxime. In case of BuChE reactivation, two compounds (K053 and K068) achieved similar results as obidoxime.
dcterms:title
Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon
skos:prefLabel
Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon
skos:notation
RIV/67985858:_____/09:00333208!RIV11-AV0-67985858
n4:aktivita
n6:S n6:P n6:Z
n4:aktivity
P(IAA603020901), S, Z(AV0Z40720504), Z(MO0FVZ0000604)
n4:cisloPeriodika
12
n4:dodaniDat
n14:2011
n4:domaciTvurceVysledku
n17:4633024
n4:druhVysledku
n9:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n8:predkladatel
n4:idSjednocenehoVysledku
330033
n4:idVysledku
RIV/67985858:_____/09:00333208
n4:jazykVysledku
n15:eng
n4:klicovaSlova
acetylcholinesterase; reactivator; oxime
n4:klicoveSlovo
n5:reactivator n5:acetylcholinesterase n5:oxime
n4:kodStatuVydavatele
CH - Švýcarská konfederace
n4:kontrolniKodProRIV
[BEB795DB603D]
n4:nazevZdroje
Molecules
n4:obor
n12:CC
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
10
n4:projekt
n18:IAA603020901
n4:rokUplatneniVysledku
n14:2009
n4:svazekPeriodika
14
n4:tvurceVysledku
Hrabinová, M. Církva, Vladimír Jun, D. Pohanka, M. Kuča, K. Musilová, L. Paleček, J. Zdarová Karasová, J. Musílek, K. Paar, M.
n4:wos
000273043200009
n4:zamer
n16:MO0FVZ0000604 n16:AV0Z40720504
s:issn
1420-3049
s:numberOfPages
7