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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F14%3A00435667%21RIV15-GA0-67985823
rdf:type
n14:Vysledek skos:Concept
dcterms:description
We tested whether the beneficial metabolic effects of LC n-3 PUFA involve the induction of Fgf21 in C57BL/6J mice fed high-fat diet (cHF), or a cHF diet supplemented with LC n-3 PUFA (cHF-F) using two experimental settings: shortterm (3 weeks) and long-term treatment (8 weeks). cHF increased plasma Fgf21 levels and hepatic Fgf21 gene expression compared with controls, but these effects were less pronounced or absent in cHF-F-fed mice. In contrast, hepatic expression of peroxisome proliferator-activated receptor (PPAR)-α target genes were more strongly induced by cHF-F than cHF, especially in the short-term treatment setting. In the long-term treatment setting, the expression of Fgf21 target genes and receptors was not differentially affected by LC n-3 PUFA. Collectively, our indings indicate that increased Fgf21 levels do not appear to be a major mechanism through which LC n-3 PUFA ameliorates high-fat-diet-associated metabolic disorders We tested whether the beneficial metabolic effects of LC n-3 PUFA involve the induction of Fgf21 in C57BL/6J mice fed high-fat diet (cHF), or a cHF diet supplemented with LC n-3 PUFA (cHF-F) using two experimental settings: shortterm (3 weeks) and long-term treatment (8 weeks). cHF increased plasma Fgf21 levels and hepatic Fgf21 gene expression compared with controls, but these effects were less pronounced or absent in cHF-F-fed mice. In contrast, hepatic expression of peroxisome proliferator-activated receptor (PPAR)-α target genes were more strongly induced by cHF-F than cHF, especially in the short-term treatment setting. In the long-term treatment setting, the expression of Fgf21 target genes and receptors was not differentially affected by LC n-3 PUFA. Collectively, our indings indicate that increased Fgf21 levels do not appear to be a major mechanism through which LC n-3 PUFA ameliorates high-fat-diet-associated metabolic disorders
dcterms:title
Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids
skos:prefLabel
Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids
skos:notation
RIV/67985823:_____/14:00435667!RIV15-GA0-67985823
n3:aktivita
n9:P n9:I
n3:aktivity
I, P(GA13-00871S)
n3:cisloPeriodika
11
n3:dodaniDat
n13:2015
n3:domaciTvurceVysledku
n4:5972450 n4:6279163 n4:4259068
n3:druhVysledku
n10:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
16693
n3:idVysledku
RIV/67985823:_____/14:00435667
n3:jazykVysledku
n16:eng
n3:klicovaSlova
fibroblast growth factor-21; long-chain n-3 polyunsaturated fatty acids
n3:klicoveSlovo
n6:long-chain%20n-3%20polyunsaturated%20fatty%20acids n6:fibroblast%20growth%20factor-21
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[CBE843CF170D]
n3:nazevZdroje
Lipids
n3:obor
n15:FB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
8
n3:projekt
n12:GA13-00871S
n3:rokUplatneniVysledku
n13:2014
n3:svazekPeriodika
49
n3:tvurceVysledku
Planavila, A. Flachs, Pavel Kopecký, Jan Giralt, M. Villarroya, F. Redondo-Angulo, I. Medříková, Daša Villarroya, J.
n3:wos
000344151800001
s:issn
0024-4201
s:numberOfPages
9
n8:doi
10.1007/s11745-014-3948-x