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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F14%3A00431311%21RIV15-GA0-67985823
rdf:type
skos:Concept n15:Vysledek
dcterms:description
CD36 is a scavenger receptor that functions in high-affinity tissue uptake of long-chain fatty acids (FAs) and contributes under excessive fat supply to lipid accumulation and metabolic dysfunction. This review describes recent evidence regarding the CD36 FA binding site and a potential mechanism for FA transfer. It also presents the view that CD36 and FA signaling coordinate fat utilization, a view that is based on newly identified CD36 actions that involve oral fat perception, intestinal fat absorption, secretion of the peptides cholecystokinin and secretin, regulation of hepatic lipoprotein output, activation of beta oxidation by muscle, and regulation of the production of the FA-derived bioactive eicosanoids CD36 is a scavenger receptor that functions in high-affinity tissue uptake of long-chain fatty acids (FAs) and contributes under excessive fat supply to lipid accumulation and metabolic dysfunction. This review describes recent evidence regarding the CD36 FA binding site and a potential mechanism for FA transfer. It also presents the view that CD36 and FA signaling coordinate fat utilization, a view that is based on newly identified CD36 actions that involve oral fat perception, intestinal fat absorption, secretion of the peptides cholecystokinin and secretin, regulation of hepatic lipoprotein output, activation of beta oxidation by muscle, and regulation of the production of the FA-derived bioactive eicosanoids
dcterms:title
Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism
skos:prefLabel
Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism
skos:notation
RIV/67985823:_____/14:00431311!RIV15-GA0-67985823
n3:aktivita
n14:I n14:P
n3:aktivity
I, P(GP13-04449P)
n3:cisloPeriodika
JULY
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n4:4429230
n3:druhVysledku
n16:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
47955
n3:idVysledku
RIV/67985823:_____/14:00431311
n3:jazykVysledku
n10:eng
n3:klicovaSlova
fat taste; chylomicron; VLDL; CCK; secretin; calcium; FA binding; phospholipase; eicosanoid
n3:klicoveSlovo
n5:secretin n5:fat%20taste n5:phospholipase n5:chylomicron n5:FA%20binding n5:CCK n5:VLDL n5:eicosanoid n5:calcium
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[C0BE6F6E4A5E]
n3:nazevZdroje
Annual Review of Nutrition
n3:obor
n13:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:projekt
n17:GP13-04449P
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
34
n3:tvurceVysledku
Kuda, Ondřej Abumrad, N. A. Pepino, M. Y. Samovski, D.
n3:wos
000348455800012
s:issn
0199-9885
s:numberOfPages
22
n12:doi
10.1146/annurev-nutr-071812-161220