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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F14%3A00431288%21RIV15-GA0-67985823
rdf:type
n13:Vysledek skos:Concept
dcterms:description
The objective of our in vivo study was to evaluate whether the impaired function of BKCa and/or KV channels is responsible for abnormal cAMP-induced vasodilatation in genetic hypertension. Under basal conditions, the vasodilator action of both K(+) channels was enhanced in SHR compared to WKY rats. However, the overall contribution of K(+) channels to cAMP-induced vasodilator mechanisms is insufficient in genetic hypertension since a concurrent activation of both K(+) channels by cAMP overproduction is necessary for the prevention of BP rise elicited by acute NO/cGMP deficiency in SHR. This might be caused by less effective activation of these K(+) channels by cAMP in SHR. In conclusion, K(+) channels seem to have higher activity in SHR, but their vasodilator action cannot match sufficiently the augmented vasoconstriction in this hypertensive strain The objective of our in vivo study was to evaluate whether the impaired function of BKCa and/or KV channels is responsible for abnormal cAMP-induced vasodilatation in genetic hypertension. Under basal conditions, the vasodilator action of both K(+) channels was enhanced in SHR compared to WKY rats. However, the overall contribution of K(+) channels to cAMP-induced vasodilator mechanisms is insufficient in genetic hypertension since a concurrent activation of both K(+) channels by cAMP overproduction is necessary for the prevention of BP rise elicited by acute NO/cGMP deficiency in SHR. This might be caused by less effective activation of these K(+) channels by cAMP in SHR. In conclusion, K(+) channels seem to have higher activity in SHR, but their vasodilator action cannot match sufficiently the augmented vasoconstriction in this hypertensive strain
dcterms:title
Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension
skos:prefLabel
Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension
skos:notation
RIV/67985823:_____/14:00431288!RIV15-GA0-67985823
n3:aktivita
n5:I n5:P n5:Z
n3:aktivity
I, P(1M0510), P(GA305/09/0336), P(GAP304/12/0259), Z(AV0Z50110509)
n3:cisloPeriodika
3
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n11:4463404 n11:2115557 n11:1477498 Behuliak, Michal
n3:druhVysledku
n18:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
22809
n3:idVysledku
RIV/67985823:_____/14:00431288
n3:jazykVysledku
n10:eng
n3:klicovaSlova
isoprenaline; cAMP; potassium channels; calcium channels
n3:klicoveSlovo
n4:isoprenaline n4:cAMP n4:potassium%20channels n4:calcium%20channels
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[C4F0541E19EB]
n3:nazevZdroje
Physiological Research
n3:obor
n9:FA
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n15:GAP304%2F12%2F0259 n15:GA305%2F09%2F0336 n15:1M0510
n3:rokUplatneniVysledku
n12:2014
n3:svazekPeriodika
63
n3:tvurceVysledku
Zicha, Josef Pintérová, Mária Kuneš, Jaroslav Behuliak, Michal
n3:wos
000339879900001
n3:zamer
n8:AV0Z50110509
s:issn
0862-8408
s:numberOfPages
11