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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F14%3A00428198%21RIV15-GA0-67985823
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Hypertension is associated with end-organ damage and thus might lead to the release of damage-associated molecular patterns (DAMPs), which are endogenous activators of TLR4 receptors. The present study aimed to elucidate whether TLR4 signalling is able to modulate vascular contractility in an experimental model of hypertension thus contributing to blood pressure regulation. NG-nitro-l-arginine methyl ester (l-NAME)-induced hypertension was blunted in TLR4(-/-) when compared with wild-type mice. Cell damage-associated TLR4 signalling might act as a direct mediator of vascular contractility providing a molecular link between inflammation and hypertension Hypertension is associated with end-organ damage and thus might lead to the release of damage-associated molecular patterns (DAMPs), which are endogenous activators of TLR4 receptors. The present study aimed to elucidate whether TLR4 signalling is able to modulate vascular contractility in an experimental model of hypertension thus contributing to blood pressure regulation. NG-nitro-l-arginine methyl ester (l-NAME)-induced hypertension was blunted in TLR4(-/-) when compared with wild-type mice. Cell damage-associated TLR4 signalling might act as a direct mediator of vascular contractility providing a molecular link between inflammation and hypertension
dcterms:title
Damage-associated molecular pattern activated Toll-like receptor 4 signalling modulates blood pressure in L-NAME-induced hypertension Damage-associated molecular pattern activated Toll-like receptor 4 signalling modulates blood pressure in L-NAME-induced hypertension
skos:prefLabel
Damage-associated molecular pattern activated Toll-like receptor 4 signalling modulates blood pressure in L-NAME-induced hypertension Damage-associated molecular pattern activated Toll-like receptor 4 signalling modulates blood pressure in L-NAME-induced hypertension
skos:notation
RIV/67985823:_____/14:00428198!RIV15-GA0-67985823
n3:aktivita
n15:Z n15:I n15:P
n3:aktivity
I, P(GA305/09/0336), Z(AV0Z50110509)
n3:cisloPeriodika
3
n3:dodaniDat
n11:2015
n3:domaciTvurceVysledku
n7:1477498
n3:druhVysledku
n18:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
9726
n3:idVysledku
RIV/67985823:_____/14:00428198
n3:jazykVysledku
n19:eng
n3:klicovaSlova
innate immunity; Toll-like receptors; reactive oxygen species; vascular contractility
n3:klicoveSlovo
n4:reactive%20oxygen%20species n4:innate%20immunity n4:Toll-like%20receptors n4:vascular%20contractility
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[7A8023C4848A]
n3:nazevZdroje
Cardiovascular Research
n3:obor
n12:FA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
14
n3:projekt
n8:GA305%2F09%2F0336
n3:rokUplatneniVysledku
n11:2014
n3:svazekPeriodika
101
n3:tvurceVysledku
Lorenz, S. Sollinger, D. Lutz, J. Schmaderer, Ch. Bluyssen, H. Eissler, R. Strand, S. Baumann, M. Witzke, O. Heemann, U. Zicha, Josef Chmielewski, S. Scherer, E. Aoqui, C.
n3:wos
000332040000016
n3:zamer
n6:AV0Z50110509
s:issn
0008-6363
s:numberOfPages
9
n5:doi
10.1093/cvr/cvt265