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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F13%3A00422469%21RIV14-MSM-67985823
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Status epilepticus (SE) induced in immature rats is associated with oxidative stress and mitochondrial dysfunction. Oxidative stress is apparently due to both the increased free radicals production and the limited antioxidant defense. Pronounced inhibition of mitochondrial complex I activity was demonstrated already during the acute phase of SE and it persists during long periods of survival following SE. The findings suggest that oxidative modification of the enzyme is most likely responsible for the sustained deficiency of complex I activity Status epilepticus (SE) induced in immature rats is associated with oxidative stress and mitochondrial dysfunction. Oxidative stress is apparently due to both the increased free radicals production and the limited antioxidant defense. Pronounced inhibition of mitochondrial complex I activity was demonstrated already during the acute phase of SE and it persists during long periods of survival following SE. The findings suggest that oxidative modification of the enzyme is most likely responsible for the sustained deficiency of complex I activity
dcterms:title
Oxidative stress in immature brain following experimentally-induced seizures Oxidative stress in immature brain following experimentally-induced seizures
skos:prefLabel
Oxidative stress in immature brain following experimentally-induced seizures Oxidative stress in immature brain following experimentally-induced seizures
skos:notation
RIV/67985823:_____/13:00422469!RIV14-MSM-67985823
n9:predkladatel
n18:ico%3A67985823
n3:aktivita
n7:I n7:P n7:Z
n3:aktivity
I, P(GA309/05/2015), P(GA309/08/0292), P(GAP302/10/0971), P(GAP303/10/0999), P(LL1204), Z(AV0Z50110509)
n3:cisloPeriodika
Suppl.1
n3:dodaniDat
n12:2014
n3:domaciTvurceVysledku
n17:3500713
n3:druhVysledku
n11:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
95088
n3:idVysledku
RIV/67985823:_____/13:00422469
n3:jazykVysledku
n19:eng
n3:klicovaSlova
immature rats; experimentally-induced seizures; oxidative stress; mitochondrial dysfunction; antioxidant defense
n3:klicoveSlovo
n5:antioxidant%20defense n5:mitochondrial%20dysfunction n5:immature%20rats n5:oxidative%20stress n5:experimentally-induced%20seizures
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[F262CD65D4AC]
n3:nazevZdroje
Physiological Research
n3:obor
n8:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:projekt
n4:GA309%2F05%2F2015 n4:LL1204 n4:GAP303%2F10%2F0999 n4:GA309%2F08%2F0292 n4:GAP302%2F10%2F0971
n3:rokUplatneniVysledku
n12:2013
n3:svazekPeriodika
62
n3:tvurceVysledku
Folbergrová, Jaroslava
n3:wos
000328901900004
n3:zamer
n15:AV0Z50110509
s:issn
0862-8408
s:numberOfPages
10