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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F13%3A00420861%21RIV14-GA0-67985823
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Several heterocyclic N-piperidine substituted salts were synthesized that were found to inhibit the specific binding of the antagonists of muscarinic receptors. One of the compounds was found tobe 3 to 8 times more potent at M2 than other subtypes of muscarinic receptors in competition binding and selective for the M1 receptors over M3 and M5 in antagonizing accumulation of inositol phosphates induced by muscarinic agonist carbachol Several heterocyclic N-piperidine substituted salts were synthesized that were found to inhibit the specific binding of the antagonists of muscarinic receptors. One of the compounds was found tobe 3 to 8 times more potent at M2 than other subtypes of muscarinic receptors in competition binding and selective for the M1 receptors over M3 and M5 in antagonizing accumulation of inositol phosphates induced by muscarinic agonist carbachol
dcterms:title
Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications
skos:prefLabel
Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications
skos:notation
RIV/67985823:_____/13:00420861!RIV14-GA0-67985823
n16:predkladatel
n17:ico%3A67985823
n3:aktivita
n19:P n19:I
n3:aktivity
I, P(GA305/09/0681)
n3:cisloPeriodika
6
n3:dodaniDat
n11:2014
n3:domaciTvurceVysledku
n7:8826897 n7:8398984
n3:druhVysledku
n18:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
109543
n3:idVysledku
RIV/67985823:_____/13:00420861
n3:jazykVysledku
n14:eng
n3:klicovaSlova
N-piperidine substituted salts; muscarinic receptor antagonists; selectivity
n3:klicoveSlovo
n8:selectivity n8:muscarinic%20receptor%20antagonists n8:N-piperidine%20substituted%20salts
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[FC6B1C038714]
n3:nazevZdroje
Journal of Heterocyclic Chemistry
n3:obor
n10:ED
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n13:GA305%2F09%2F0681
n3:rokUplatneniVysledku
n11:2013
n3:svazekPeriodika
50
n3:tvurceVysledku
Boulos, J. Jakubík, Jan Randáková, Alena Avila, C.
n3:wos
000327293700018
s:issn
0022-152X
s:numberOfPages
5
n5:doi
10.1002/jhet.1742