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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F13%3A00392574%21RIV14-GA0-67985823
rdf:type
n12:Vysledek skos:Concept
dcterms:description
The binding of ATP to trimeric P2X receptors (P2XR) causes an enlargement of the receptor extracellular vestibule, leading to opening of the cation-selective transmembrane pore. We identified five residues in the extracellulat vestibule, V49, Y54, Q55, F324, and G325, as critical for P2X4R function The binding of ATP to trimeric P2X receptors (P2XR) causes an enlargement of the receptor extracellular vestibule, leading to opening of the cation-selective transmembrane pore. We identified five residues in the extracellulat vestibule, V49, Y54, Q55, F324, and G325, as critical for P2X4R function
dcterms:title
Multiple Roles of the Extracellular Vestibule Amino Acid Residues in the Function of the Rat P2X4 Receptor Multiple Roles of the Extracellular Vestibule Amino Acid Residues in the Function of the Rat P2X4 Receptor
skos:prefLabel
Multiple Roles of the Extracellular Vestibule Amino Acid Residues in the Function of the Rat P2X4 Receptor Multiple Roles of the Extracellular Vestibule Amino Acid Residues in the Function of the Rat P2X4 Receptor
skos:notation
RIV/67985823:_____/13:00392574!RIV14-GA0-67985823
n12:predkladatel
n14:ico%3A67985823
n4:aktivita
n6:Z n6:P n6:I
n4:aktivity
I, P(GBP304/12/G069), P(IAA500110910), Z(AV0Z50110509)
n4:cisloPeriodika
3
n4:dodaniDat
n15:2014
n4:domaciTvurceVysledku
n10:4751620 n10:3526070 Kuzyk, Pavlo Rokic, Milos Boro n10:3063461
n4:druhVysledku
n9:J
n4:duvernostUdaju
n20:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
90148
n4:idVysledku
RIV/67985823:_____/13:00392574
n4:jazykVysledku
n8:eng
n4:klicovaSlova
ATP; purinergic P2X receptor channels; transmembrane domain; extracellular vestibule; gating; ivermectin
n4:klicoveSlovo
n5:extracellular%20vestibule n5:purinergic%20P2X%20receptor%20channels n5:transmembrane%20domain n5:gating n5:ATP n5:ivermectin
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[ADC4B84E4574]
n4:nazevZdroje
PLoS ONE
n4:obor
n13:ED
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
6
n4:projekt
n17:IAA500110910 n17:GBP304%2F12%2FG069
n4:rokUplatneniVysledku
n15:2013
n4:svazekPeriodika
8
n4:tvurceVysledku
Kuzyk, Pavlo Tvrdoňová, Vendula Vávra, Vojtěch Zemková, Hana Rokic, Milos Boro Stojilkovic, S. S.
n4:wos
000316546400037
n4:zamer
n19:AV0Z50110509
s:issn
1932-6203
s:numberOfPages
11
n7:doi
10.1371/journal.pone.0059411