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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F13%3A00391719%21RIV14-MSM-67985823
rdf:type
n14:Vysledek skos:Concept
dcterms:description
In control animals activities of individual antioxidant enzymes revealed different changes during the studied postnatal period (PD12-PD47).In animals in which seizures were induced by DL-homocysteic acid, the activity of total SOD, SOD1 and particularly SOD2 significantly increased at 20 h and 6 days of survival following the seizures.Upregulation of SOD2 was also confirmed in mitochondria at the protein level by immunoblotting.The activities of other antioxidant enzymes did not differ from the appropriate controls. The findings suggest that antioxidant defense in brain of immature animals during seizures is limited and may thus contribute to the occurrence of oxidative stress In control animals activities of individual antioxidant enzymes revealed different changes during the studied postnatal period (PD12-PD47).In animals in which seizures were induced by DL-homocysteic acid, the activity of total SOD, SOD1 and particularly SOD2 significantly increased at 20 h and 6 days of survival following the seizures.Upregulation of SOD2 was also confirmed in mitochondria at the protein level by immunoblotting.The activities of other antioxidant enzymes did not differ from the appropriate controls. The findings suggest that antioxidant defense in brain of immature animals during seizures is limited and may thus contribute to the occurrence of oxidative stress
dcterms:title
Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2) Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2)
skos:prefLabel
Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2) Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2)
skos:notation
RIV/67985823:_____/13:00391719!RIV14-MSM-67985823
n14:predkladatel
n18:ico%3A67985823
n3:aktivita
n9:I n9:P n9:Z
n3:aktivity
I, P(GA309/08/0292), P(GAP303/10/0999), P(LL1204), Z(AV0Z50110509)
n3:cisloPeriodika
2
n3:dodaniDat
n13:2014
n3:domaciTvurceVysledku
n7:1407953 n7:8943222 n7:3500713 n7:6212735
n3:druhVysledku
n5:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
61452
n3:idVysledku
RIV/67985823:_____/13:00391719
n3:jazykVysledku
n6:eng
n3:klicovaSlova
immature rats; DL-homocysteic acid-induced seizures; long periods of survival following the seizures; the antioxidant enzyme activities; protein levels of SOD; upregulation of SOD2 following the seizures
n3:klicoveSlovo
n10:the%20antioxidant%20enzyme%20activities n10:upregulation%20of%20SOD2%20following%20the%20seizures n10:DL-homocysteic%20acid-induced%20seizures n10:long%20periods%20of%20survival%20following%20the%20seizures n10:immature%20rats n10:protein%20levels%20of%20SOD
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[3EED15466A24]
n3:nazevZdroje
International Journal of Developmental Neuroscience
n3:obor
n16:FH
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n11:LL1204 n11:GA309%2F08%2F0292 n11:GAP303%2F10%2F0999
n3:rokUplatneniVysledku
n13:2013
n3:svazekPeriodika
31
n3:tvurceVysledku
Folbergrová, Jaroslava Houštěk, Josef Ješina, Pavel Nůsková, Hana
n3:wos
000314557500005
n3:zamer
n19:AV0Z50110509
s:issn
0736-5748
s:numberOfPages
8
n20:doi
10.1016/j.ijdevneu.2012.11.011