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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F12%3A00381028%21RIV13-MZ0-67985823
rdf:type
n9:Vysledek skos:Concept
dcterms:description
We have developed novel neuroactive steroid pregnanolone glutamate (3alpfa5beta-P-Glu). 3alpha5beta-P-Glu acts as a use-dependent NMDA receptor antagonist. 3alpha5beta-P-Glu reversed spatial learning deficit in an animal model of schizophrenia. 3alpha5beta-P-Glu did not influence spatial learning of intact animals. 3alpha5beta-P-Glu may represent procognitive drug without side effects We have developed novel neuroactive steroid pregnanolone glutamate (3alpfa5beta-P-Glu). 3alpha5beta-P-Glu acts as a use-dependent NMDA receptor antagonist. 3alpha5beta-P-Glu reversed spatial learning deficit in an animal model of schizophrenia. 3alpha5beta-P-Glu did not influence spatial learning of intact animals. 3alpha5beta-P-Glu may represent procognitive drug without side effects
dcterms:title
3 alpha 5 beta-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia 3 alpha 5 beta-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia
skos:prefLabel
3 alpha 5 beta-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia 3 alpha 5 beta-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia
skos:notation
RIV/67985823:_____/12:00381028!RIV13-MZ0-67985823
n9:predkladatel
n17:ico%3A67985823
n3:aktivita
n6:Z n6:I n6:P
n3:aktivity
I, P(NS10365), Z(AV0Z50110509)
n3:cisloPeriodika
1
n3:dodaniDat
n8:2013
n3:domaciTvurceVysledku
n5:1499777 n5:1435604 n5:1924516 n5:2614510 n5:8125023 Holubová, Kristina
n3:druhVysledku
n18:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
183381
n3:idVysledku
RIV/67985823:_____/12:00381028
n3:jazykVysledku
n15:eng
n3:klicovaSlova
schizophrenia-like behavior; MK-801; use-dependent; NMDA antagonist; anxiety; pregnanolone glutamate; Carousel maze
n3:klicoveSlovo
n13:MK-801 n13:pregnanolone%20glutamate n13:anxiety n13:Carousel%20maze n13:use-dependent n13:schizophrenia-like%20behavior n13:NMDA%20antagonist
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[40647E4804B2]
n3:nazevZdroje
Behavioural Brain Research
n3:obor
n14:FH
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
8
n3:projekt
n12:NS10365
n3:rokUplatneniVysledku
n8:2012
n3:svazekPeriodika
235
n3:tvurceVysledku
Vyklický ml., Ladislav Svoboda, Jan Rambousek, Lukáš Stuchlík, Aleš Valeš, Karel Chodounská, Hana Holubová, Kristina Bubeniková-Valešová, V.
n3:wos
000309095900011
n3:zamer
n20:AV0Z50110509
s:issn
0166-4328
s:numberOfPages
7
n19:doi
10.1016/j.bbr.2012.07.020