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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F12%3A00380467%21RIV13-GA0-67985823
rdf:type
n10:Vysledek skos:Concept
dcterms:description
We also searched for the age-dependent impact of environmental and pharmacological interventions, which modify the development of high blood pressure and/or organ damage, if they influence the salt-sensitive organism in particular critical periods of development (developmental windows). Thus, severe self-sustaining salt hypertension in young Dahl rats is characterized by pronounced dysbalance between augmented sympathetic hyperactivity and relative nitric oxide deficiency, attenuated baroreflex as well as by a major increase of residual blood pressure indicating profound remodeling of resistance vessels. Salt hypertension development in young but not in adult Dahl rats can be attenuated by preventive increase of potassium or calcium intake. On the contrary, moderate salt hypertension in adult Dahl rats is attenuated by superoxide scavenging or endothelin-A receptor blockade which do not affect salt hypertension development in young animals We also searched for the age-dependent impact of environmental and pharmacological interventions, which modify the development of high blood pressure and/or organ damage, if they influence the salt-sensitive organism in particular critical periods of development (developmental windows). Thus, severe self-sustaining salt hypertension in young Dahl rats is characterized by pronounced dysbalance between augmented sympathetic hyperactivity and relative nitric oxide deficiency, attenuated baroreflex as well as by a major increase of residual blood pressure indicating profound remodeling of resistance vessels. Salt hypertension development in young but not in adult Dahl rats can be attenuated by preventive increase of potassium or calcium intake. On the contrary, moderate salt hypertension in adult Dahl rats is attenuated by superoxide scavenging or endothelin-A receptor blockade which do not affect salt hypertension development in young animals
dcterms:title
Age-dependent salt hypertension in Dahl rats: fifty years of research Age-dependent salt hypertension in Dahl rats: fifty years of research
skos:prefLabel
Age-dependent salt hypertension in Dahl rats: fifty years of research Age-dependent salt hypertension in Dahl rats: fifty years of research
skos:notation
RIV/67985823:_____/12:00380467!RIV13-GA0-67985823
n10:predkladatel
n15:ico%3A67985823
n3:aktivita
n9:P n9:I n9:Z
n3:aktivity
I, P(1M0510), P(GA305/09/0336), P(GAP304/12/0259), Z(AV0Z50110509)
n3:cisloPeriodika
Suppl.1
n3:dodaniDat
n13:2013
n3:domaciTvurceVysledku
n8:4935985 n8:9905200 n8:1477498 n8:8128618 n8:4463404 Behuliak, Michal n8:7094507 n8:4791975 n8:8260915
n3:druhVysledku
n6:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
121306
n3:idVysledku
RIV/67985823:_____/12:00380467
n3:jazykVysledku
n19:eng
n3:klicovaSlova
blood pressure; cell membrane transport; hemodynamics; vasoactive systems; cell calcium handling
n3:klicoveSlovo
n11:cell%20calcium%20handling n11:cell%20membrane%20transport n11:blood%20pressure n11:vasoactive%20systems n11:hemodynamics
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[15C8B6A47A2E]
n3:nazevZdroje
Physiological Research
n3:obor
n17:FA
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
9
n3:projekt
n4:1M0510 n4:GA305%2F09%2F0336 n4:GAP304%2F12%2F0259
n3:rokUplatneniVysledku
n13:2012
n3:svazekPeriodika
61
n3:tvurceVysledku
Rauchová, Hana Kadlecová, Michaela Kuneš, Jaroslav Dobešová, Zdenka Vokurková, Martina Hojná, Silvie Zicha, Josef Behuliak, Michal Vaněčková, Ivana
n3:wos
000307133700005
n3:zamer
n5:AV0Z50110509
s:issn
0862-8408
s:numberOfPages
54