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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F12%3A00380295%21RIV13-GA0-67985823
rdf:type
skos:Concept n10:Vysledek
dcterms:description
We investigated here whether n-3 LC-PUFA could elicit additive beneficial effects on metabolic flexibility when combined with a TZD drug rosiglitazone in mice. Metabolomic and gene expression analyses in the muscle suggested distinct and complementary effects of the interventions, with n-3 LC-PUFA supporting complete oxidation of fatty acids in mitochondria and the combination with n-3 LC-PUFA and rosiglitazone augmenting insulin sensitivity by the modulation of branched-chain amino acid metabolism. These beneficial metabolic effects were associated with the activation of the switch between glycolytic and oxidative muscle fibers, especially in mice fed combined diet of n-3 LC-PUFA and rosiglitazone We investigated here whether n-3 LC-PUFA could elicit additive beneficial effects on metabolic flexibility when combined with a TZD drug rosiglitazone in mice. Metabolomic and gene expression analyses in the muscle suggested distinct and complementary effects of the interventions, with n-3 LC-PUFA supporting complete oxidation of fatty acids in mitochondria and the combination with n-3 LC-PUFA and rosiglitazone augmenting insulin sensitivity by the modulation of branched-chain amino acid metabolism. These beneficial metabolic effects were associated with the activation of the switch between glycolytic and oxidative muscle fibers, especially in mice fed combined diet of n-3 LC-PUFA and rosiglitazone
dcterms:title
Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice
skos:prefLabel
Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice
skos:notation
RIV/67985823:_____/12:00380295!RIV13-GA0-67985823
n10:predkladatel
n15:ico%3A67985823
n3:aktivita
n4:I n4:P
n3:aktivity
I, P(7E10059), P(GA303/08/0664)
n3:cisloPeriodika
8
n3:dodaniDat
n14:2013
n3:domaciTvurceVysledku
n8:5972450 n8:4429230 n8:2846535 n8:4671724 n8:6642942 n8:6758932 n8:4259068 n8:8280622 n8:1926217 n8:6279163
n3:druhVysledku
n9:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
161417
n3:idVysledku
RIV/67985823:_____/12:00380295
n3:jazykVysledku
n19:eng
n3:klicovaSlova
n-3 LC-PUFA; TZD; muscle insulin sensitivity
n3:klicoveSlovo
n5:n-3%20LC-PUFA n5:muscle%20insulin%20sensitivity n5:TZD
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[7E7BF1CFCAEA]
n3:nazevZdroje
PLoS ONE
n3:obor
n16:FB
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
17
n3:projekt
n13:7E10059 n13:GA303%2F08%2F0664
n3:rokUplatneniVysledku
n14:2012
n3:svazekPeriodika
7
n3:tvurceVysledku
Hensler, Michal Kůs, Vladimír Horáková, Olga Keijer, J. Kopecký, Jan Adamski, J. Bunschoten, A. Prehn, C. Flachs, Pavel Bardová, Kristina Rossmeisl, Martin Medříková, Daša Illig, T. Janovská, Petra van Schothorst, E. M. Wang-Sattler, R. Kuda, Ondřej
n3:wos
000308221300026
s:issn
1932-6203
s:numberOfPages
17
n17:doi
10.1371/journal.pone.0043764